Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Diez-Martinez, J. (Javier) | |
dc.creator | Panizo, A. (Ángel) | |
dc.creator | Hernandez, M. (Milagros) | |
dc.creator | Pardo, J. (Javier) | |
dc.date.accessioned | 2011-12-02T13:45:48Z | - |
dc.date.available | 2011-12-02T13:45:48Z | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Diez J, Panizo A, Hernandez M, Pardo J. Is the regulation of apoptosis altered in smooth muscle cells of adult spontaneously hypertensive rats?. Hypertension 1997 Mar;29(3):776-780. | es_ES |
dc.identifier.issn | 0194-911X | - |
dc.identifier.uri | https://hdl.handle.net/10171/20090 | - |
dc.description.abstract | Whereas the protein product of the Bcl-2 gene inhibits apoptosis, the protein product of the Bax gene acts as a promoter of apoptosis. To gain insight into the regulation of apoptosis in vascular smooth muscle cells in arterial hypertension, we investigated the expression of the proteins Bcl-2 and Bax in small intramyocardial arteries of 36-week-old normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). In addition, 16-week-old SHR were treated for 20 weeks with the angiotensin-converting enzyme inhibitor quinapril and killed at 36 weeks of age. We measured the percentages of smooth muscle cells expressing these proteins using monoclonal antibodies and the avidin-biotin immunoperoxidase method. Compared with WKY, untreated SHR exhibited increased (P<.001) Bcl-2 expression and similar Bax expression. Values of Bcl-2 measured in quinapril-treated SHR were significantly lower than values measured in untreated SHR and similar to values measured in WKY. Quinapril-treated SHR showed higher (P<.001) Bax expression than WKY and untreated SHR. Bcl-2 expression was directly correlated with systolic pressure. Inverse correlations were found between the expression of Bax and the activities of both cardiac and circulating angiotensin-converting enzyme. These findings suggest that smooth muscle cell apoptosis might be inhibited in small arteries of adult SHR as a consequence of an excess of the protein Bcl-2. In addition, our results suggest that chronic angiotensin-converting enzyme inhibition might restore the susceptibility to apoptosis in these cells through stimulation of the protein Bax. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American heart association | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Apoptosis | es_ES |
dc.subject | Hypertension, arterial | es_ES |
dc.subject | Muscle, smooth, vascular | es_ES |
dc.title | Is the regulation of apoptosis altered in smooth muscle cells of adult spontaneously hypertensive rats? | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1161/ 01.HYP.29.3.776 | es_ES |
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