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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

Lesion of the centromedian thalamic nucleus in MPTP-treated monkeys
Autor(es) : Lanciego, J.L. (José Luis)
Rodriguez-Oroz, M.C. (María Cruz)
Blesa, F.J. (F.J.)
Alvarez-Erviti, L. (Lydia)
Guridi, J. (Jorge)
Barroso-Chinea, P. (P.)
Smith, Y. (Yoland)
Obeso, J.A. (José A.)
Palabras clave : intralaminar thalamic nuclei
MPTP monkey model
Kainic acid lesion
Parkinson’s disease
Fecha incorporación: 2008
Editorial : Wiley Blackwell
Versión del editor: http://bit.ly/uF6SPz
ISSN: 1531-8257
Cita: Lanciego JL, Rodriguez-Oroz MC, Blesa FJ, Alvarez-Erviti L, Guridi J, Barroso-Chinea P, et al. Lesion of the centromedian thalamic nucleus in MPTP-treated monkeys. Mov Disord 2008 Apr 15;23(5):708-715.
Resumen
The caudal intralaminar nuclei are a major source of glutamatergic afferents to the basal ganglia. Experiments in the 6-hydroxydopamine rat model have shown that the parafascicular nucleus is overactive and its lesion alleviates basal ganglia neurochemical abnormalities associated with dopamine depletion. Accordingly, removal of this excitatory innervation of the basal ganglia could have a beneficial value in the parkinsonian state. To test this hypothesis, unilateral kainate-induced chemical ablation of the centromedian thalamic nucleus (CM) has been performed in MPTP-treated monkeys. Successful lesions restricted to the CM boundaries (n = 2) without spreading over other neighboring thalamic nuclei showed an initial, short-lasting, and mild change in the parkinsonian motor scale but no effect against levodopa-induced dyskinesias. The lack of significant and persistent motor improvement leads us to conclude that unilateral selective lesion of the CM alone cannot be considered as a suitable surgical approach for the treatment of PD or levodopa-induced dyskinesias. The role of the caudal intralaminar nuclei in the pathophysiology of movement disorders of basal ganglia origin remains to be clarified.
Enlace permanente: http://hdl.handle.net/10171/20125
Aparece en las colecciones: DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

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