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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Mariano, J. M. (Jennifer M.) | - |
dc.creator | Montuenga-Badia, L.M. (Luis M.) | - |
dc.creator | Prentice, M. (Margaret A.) | - |
dc.creator | Cuttitta, F. (Frank) | - |
dc.creator | Jakowlew, S.B. (Sonia B.) | - |
dc.date.accessioned | 2011-12-09T18:56:42Z | - |
dc.date.available | 2011-12-09T18:56:42Z | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Mariano JM, Montuenga LM, Prentice MA, Cuttitta F, Jakowlew SB. Concurrent and distinct transcription and translation of transforming growth factor-beta type I and type II receptors in rodent embryogenesis. Int J Dev Biol 1998 Nov;42(8):1125-1136. | es_ES |
dc.identifier.issn | 1696-3547 | - |
dc.identifier.uri | https://hdl.handle.net/10171/20166 | - |
dc.description.abstract | The transforming growth factor-betas (TGF-betas) are multifunctional regulatory polypeptides that play a crucial role in many cell processes and function through a set of cell surface protein receptors that includes TGF-beta type I (RI) and type II (RII). The present study reports a comprehensive comparison of the patterns of expression of TGF-beta RI and RII proteins and mRNAs in the developing mouse embryo using immunohistochemical and in situ hybridization analyses. Although widespread expression of both TGF-beta receptors was detected throughout the embryonic development period so that many similarities occur in localization of the TGF-beta receptors, TGF-beta RI was expressed in a well-defined, non-uniform pattern that was different in many respects from that of TGF-beta RII. Whereas higher levels of TGF-beta RI compared to TGF-beta RII were detected in some tissues of the embryo at the beginning of organogenesis, the level of TGF-beta RII increased more dramatically than that of TGF-beta RI during late organogenesis; this was especially true in many neural structures where TGF-beta RI and RII were comparable by day 16. The lung, kidney and intestine, in which epithelial-mesenchymal interactions occur, showed a complex pattern of TGF-beta RI and Rll expression. Additionally, northern blot hybridization and reverse transcription-polymerase chain reaction (RT-PCR) amplification showed non-uniform expression of the transcripts for TGF-beta RI and RII in embryonic and adult mouse and rat tissues. These data show that regulation of TGF-beta1 RI and RII occurs concurrently, but distinctly, in a spatial and temporal manner in rodent embryogenesis which may allow control of signal transduction of TGF-beta during development. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | University of the Basque Country Press | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Grow Factors Receptor | es_ES |
dc.subject | Expression | es_ES |
dc.subject | Development | es_ES |
dc.subject | Organogenesis | es_ES |
dc.subject | Mouse embryo | es_ES |
dc.title | Concurrent and distinct transcription and translation of transforming growth factor-beta type I and type II receptors in rodent embryogenesis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.ijdb.ehu.es/web/paper.php?doi=9879710 | es_ES |
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