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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Altered NCAM expression associated with the cholinergic system in Alzheimer's disease
Autor(es) : Aisa, B. (Bárbara)
Gil-Bea, F.J. (Francisco J.)
Solas, M. (Maite)
Garcia-Alloza, M. (Mónica)
Chen, C.P. (Christopher P.)
Lai, M.K. (Mitchell K.)
Francis, P.T. (Paul T.)
Ramirez, M.J. (María Javier)
Palabras clave : BDNF
ChAT
Cognitive deficits
Frontal cortex (BA10),
MMSE
Plasticity
Temporal cortex (BA20)
Fecha incorporación: 2010
Editorial : Ios Press
Versión del editor: http://iospress.metapress.com/content/740647152186541n/
ISSN: 1875-8908
Cita: Aisa B, Gil-Bea FJ, Solas M, Garcia-Alloza M, Chen CP, Lai MK, et al. Altered NCAM expression associated with the cholinergic system in Alzheimer's disease. J Alzheimers Dis 2010;20(2):659-668.
Resumen
Neurotransmitter system dysfunction and synapse loss have been recognized as hallmarks of Alzheimer's disease (AD). Our hypothesis is that specific neurochemical populations of neurons might be more vulnerable to degeneration in AD due to particular deficits in synaptic plasticity. We have studied, in postmortem brain tissue, the relationship between levels of synaptic markers (NCAM and BDNF), neurochemical measurements (cholinacetyltransferase activity, serotonin, dopamine, GABA, and glutamate levels), and clinical data (cognitive status measured as MMSE score). NCAM levels in frontal and temporal cortex from AD patients were significantly lower than control patients. Interestingly, these reductions in NCAM levels were associated to an ApoE4 genotype. Levels of BDNF were also significantly reduced in both frontal and temporal regions in AD patients. The ratio between plasticity markers and neurochemical measurements was used to study which of the neurochemical populations was particularly associated to plasticity changes. In both the frontal and temporal cortex, there was a significant reduction in the ChAT/NCAM ratio in AD samples compared to controls. None of the ratios to BDNF were different between control and AD samples. Furthermore, Pearson's product moment showed a significant positive correlation between MMSE score and the ChAT/NCAM ratio in frontal cortex (n=19; r=0.526*; p=0.037) as well as in temporal cortex (n=19; r=0.601*; p=0.018) in AD patients. Altogether, these data suggest a potential involvement of NCAM expressing neurons in the cognitive deficits in AD.
Enlace permanente: http://hdl.handle.net/10171/20185
Aparece en las colecciones: DA - Farmacia - Farmacología - Artículos de revista
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista

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