Full metadata record
DC Field | Value | Language |
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dc.creator | Marcos, B. (Beatriz) | - |
dc.creator | Gil-Bea, F.J. (Francisco J.) | - |
dc.creator | Hirst, W.D. (Warren D.) | - |
dc.creator | Garcia-Alloza, M. (Mónica) | - |
dc.creator | Ramirez, M.J. (María Javier) | - |
dc.date.accessioned | 2011-12-13T09:46:54Z | - |
dc.date.available | 2011-12-13T09:46:54Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Marcos B, Gil-Bea FJ, Hirst WD, Garcia-Alloza M, Ramirez MJ. Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release. Eur J Neurosci 2006 Sep;24(5):1299-1306. | es_ES |
dc.identifier.issn | 1460-9568 | - |
dc.identifier.uri | https://hdl.handle.net/10171/20198 | - |
dc.description.abstract | The involvement of the cholinergic system in learning and memory together with the cognitive enhancing properties of 5-HT6 receptor antagonists led us to study the relationship between 5-HT6 receptors and cholinergic neurotransmission. A selective cholinergic lesion, induced by injection of the immunotoxin 192-IgG-Saporin into the nucleus basalis magnocellularis, failed to alter the density of 5-HT6 receptor mRNA or protein expression in the deafferentated frontal cortex, suggesting that 5-HT6 receptors are not located on cholinergic neurons. The 5-HT6 receptor antagonist SB-357134 (0.001-1 microM) induced a concentration-dependant K+-evoked [3H]acetylcholine (ACh) release in vitro in rat cortical and striatal slices, which was blocked by tetrodotoxin. SB-357134, up to 1 microM, stimulated glutamate release in cortical and striatal slices. In the cortex, riluzole (1 microM) blocked the SB-357134-induced K+-stimulated [3H]ACh release, and simultaneous administration of MK-801 (1 microM) and SB-357134 (0.05 microM) elicited an increase in K+-evoked ACh release. In the striatum, SB-357134, 1 microM, decreased dopamine release, and the increase in K+-evoked [3H]ACh release induced by 5-HT6 receptor blockade was reversed by the D1 receptor antagonist, SCH23390 (1 microM). In both the frontal cortex and striatum, bicuculline, 1 microM, showed no effect on SB-357134-evoked [3H]ACh. These results are discussed in terms of neurochemical mechanisms involved in 5-HT6 receptor functions. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Blackwell Publishing | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Cholinergic lesion | es_ES |
dc.subject | Dopaminergic system | es_ES |
dc.subject | Glutamatergic system | es_ES |
dc.subject | In vitro release | es_ES |
dc.subject | Rat | es_ES |
dc.title | Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2006.05003.x/abstract | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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