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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit
Autor(es) : Gil-Bea, F.J. (Francisco J.)
Garcia-Alloza, M. (Mónica)
Dominguez, J. (Jon)
Marcos, B. (Beatriz)
Ramirez, M.J. (María Javier)
Palabras clave : Acetylcholine (ACh)
Acetylcholinesterase (AChE)
Cholinacetyltransferase (ChAT)
Human
Cognitive deficit
Rat
Fecha incorporación: 2005
Editorial : Elsevier
Versión del editor: http://www.sciencedirect.com/science/article/pii/S0304394004013539
ISSN: 1872-7972
Cita: Gil-Bea FJ, Garcia-Alloza M, Dominguez J, Marcos B, Ramirez MJ. Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit. Neurosci Lett 2005 Feb 25;375(1):37-41.
Resumen
Cognitive deficits in neuropsychiatric disorders, such as Alzheimer's disease (AD), have been closely related to cholinergic deficits. We have compared different markers of cholinergic function to assess the best biomarker of cognitive deficits associated to cholinergic hypoactivity. In post-mortem frontal cortex from AD patients, acetylcholine (ACh) levels, cholinacetyltransferase (ChAT) and acetylcholinesterase (AChE) activity were all reduced compared to controls. Both ChAT and AChE activity showed a significant correlation with cognitive deficits. In the frontal cortex of rats with a selective cholinergic lesion, all cholinergic parameters measured (ACh levels, ChAT and AChE activities, "in vitro" and "in vivo" basal ACh release) were significantly reduced. AChE activity was associated to ChAT activity, and even more, to "in vivo" and "in vitro" basal ACh release. Quantification of AChE activity is performed by an easy and cheap method and therefore, these results suggest that determination of AChE activity may be used as an effective first step method to evaluate cholinergic deficits.
Enlace permanente: http://hdl.handle.net/10171/20232
Aparece en las colecciones: DA - Farmacia - Farmacología - Artículos de revista
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista

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