Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Hervas-Stubbs, S. (Sandra) | - |
dc.creator | Perez-Gracia, J.L. (Jose Luis) | - |
dc.creator | Rouzaut, A. (Ana) | - |
dc.creator | Fernandez-Sanmamed, M. (Miguel) | - |
dc.creator | Bon, A. (Agnes) Le | - |
dc.creator | Melero, I. (Ignacio) | - |
dc.date.accessioned | 2011-12-20T11:55:52Z | - |
dc.date.available | 2011-12-20T11:55:52Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I. Direct effects of type I interferons on cells of the immune system. Clin Cancer Res 2011 May 1;17(9):2619-2627. | es_ES |
dc.identifier.issn | 1557-3265 | - |
dc.identifier.uri | https://hdl.handle.net/10171/20294 | - |
dc.description.abstract | Type I interferons (IFN-I) are well-known inducers of tumor cell apoptosis and antiangiogenesis via signaling through a common receptor interferon alpha receptor (IFNAR). IFNAR induces the Janus activated kinase-signal transducer and activation of transcription (JAK-STAT) pathway in most cells, along with other biochemical pathways that may differentially operate, depending on the responding cell subset, and jointly control a large collection of genes. IFNs-I were found to systemically activate natural killer (NK) cell activity. Recently, mouse experiments have shown that IFNs-I directly activate other cells of the immune system, such as antigen-presenting dendritic cells (DC) and CD4 and CD8 T cells. Signaling through the IFNAR in T cells is critical for the acquisition of effector functions. Cross-talk between IFNAR and the pathways turned on by other surface lymphocyte receptors has been described. Importantly, IFNs-I also increase antigen presentation of the tumor cells to be recognized by T lymphocytes. These IFN-driven immunostimulatory pathways offer opportunities to devise combinatorial immunotherapy strategies. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Association for Cancer Research | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/201842 | - |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Cells/drug effects | es_ES |
dc.subject | Immune System/drug effects | es_ES |
dc.subject | Interferon Type I/pharmacology | es_ES |
dc.title | Direct effects of type I interferons on cells of the immune system | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://clincancerres.aacrjournals.org/content/17/9/2619 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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