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Intratumoural administration of dendritic cells: hostile environment and help by gene therapy
Autor(es) : Huarte, E. (Eduardo)
Tirapu, I. (Íñigo)
Arina, A. (Ainhoa)
Vera, M. (María)
Alfaro, C. (Carlos)
Palencia, B. (Belén)
Busto, V. (Victoria)
Marin, V. (Verónica)
Mazzolini, G. (Guillermo)
Melero, I. (Ignacio)
Palabras clave : Anticancer
Delivery
Dendritic cells
Gene therapy
Intratumoural administration
Fecha incorporación: 2005
Editorial : Informa Healthcare
Versión del editor: http://informahealthcare.com/doi/abs/10.1517/14712598.5.1.7
ISSN: 1744-7682
Cita: Huarte E, Tirapu I, Arina A, Vera M, Alfaro C, Murillo O, et al. Intratumoural administration of dendritic cells: hostile environment and help by gene therapy. Expert Opin Biol Ther 2005 Jan;5(1):7-22.
Resumen
Like paratroopers in special operations, dendritic cells (DCs) can be deployed behind the enemy borders of malignant tissue to ignite an antitumour immune response. 'Cross-priming T cell responses' is the code name for their mission, which consists of taking up antigen from transformed cells or their debris, migrating to lymphoid tissue ferrying the antigenic cargo, and meeting specific T cells. This must be accomplished in such an immunogenic manner that specific T lymphocytes would mount a robust enough response as to fully reject the malignancy. To improve their immunostimulating activity, local gene therapy can be very beneficial, either by transfecting DCs with genes enhancing their performance, or by preparing tumour tissue with pro-inflammatory mediators. In addition, endogenous DCs from the tumour host can be attracted into the malignant tissue following transfection of certain chemokine genes into tumour cells. On their side, tumour stroma and malignant cells set up a hostile immunosuppressive environment for artificially released or attracted DCs. This milieu is usually rich in transforming growth factor-beta, vascular endothelial growth factor, and IL-10, -6 and -8, among other substances that diminish DC performance. Several molecular strategies are being devised to interfere with the immunosuppressive actions of these substances and to further enhance the level of anticancer immunity achieved after artificial release of DCs intratumourally.
Enlace permanente: http://hdl.handle.net/10171/20418
Aparece en las colecciones: DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista

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