Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Zabaleta, A. (Aintzane) | - |
dc.creator | Llopiz, D. (Diana) | - |
dc.creator | Arribillaga, L. (Laura) | - |
dc.creator | Silva, L. (Leyre) | - |
dc.creator | Riezu-Boj, J.I. (José Ignacio) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.date.accessioned | 2012-01-16T09:24:46Z | - |
dc.date.available | 2012-01-16T09:24:46Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Zabaleta A, Llopiz D, Arribillaga L, Silva L, Riezu-Boj JI, Lasarte JJ, et al. Vaccination against hepatitis C virus with dendritic cells transduced with an adenovirus encoding NS3 protein. Mol Ther 2008 Jan;16(1):210-217. | es_ES |
dc.identifier.issn | 1525-0016 | - |
dc.identifier.uri | https://hdl.handle.net/10171/20430 | - |
dc.description.abstract | Chronic infection by hepatitis C virus (HCV) is characterized by the absence of efficient antiviral T-cell responses. Thus, vaccination strategies to induce strong anti-HCV T-cell responses are of paramount importance for prophylactic and therapeutic purposes. Dendritic cells (DCs) are the most potent antigen presenting cells; therefore, immunization with these cells loaded with viral antigens offers a new approach for induction of antiviral immunity. Here we show that immunization with DCs transfected with an adenovirus encoding non-structural 3 protein, from HCV (AdNS3), induced multiepitopic CD4 T helper cell 1 (Th1) and CD8 T-cell responses in different mouse strains. These responses prevented the growth of a tumorexpressing HCV proteins, in short- and long-term experiments. Moreover, immunization with AdNS3-transfected DCs did not induce anti-adenoviral antibodies, as compared to direct immunization with AdNS3, but elicited T-cell responses even in the presence of pre-existing anti-adenoviral antibodies. Finally, responses induced by this protocol down-regulated the expression of HCV RNA in the liver. In conclusion, DCs transfected with AdNS3 may prove to be an efficient anti-HCV vaccine. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature publishing group | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Dendritic Cells/transplantation | es_ES |
dc.subject | Hepacivirus/immunology | es_ES |
dc.subject | Transduction, Genetic | es_ES |
dc.subject | Viral Hepatitis Vaccines/administration & dosage | es_ES |
dc.subject | Viral Nonstructural Proteins/genetics | es_ES |
dc.title | Vaccination against hepatitis C virus with dendritic cells transduced with an adenovirus encoding NS3 protein | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1038/sj.mt.6300333 | es_ES |
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