Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Ruiz, M. (Marta) | - |
dc.creator | Kobayashi, H. (Hiroya) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.creator | Celis, E. (Esteban) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.date.accessioned | 2012-01-16T09:35:41Z | - |
dc.date.available | 2012-01-16T09:35:41Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Ruiz M, Kobayashi H, Lasarte JJ, Prieto J, Borras-Cuesta F, Celis E, at al. Identification and characterization of a T-helper peptide from carcinoembryonic antigen. Clin Cancer Res 2004 Apr 15;10(8):2860-2867. | es_ES |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://hdl.handle.net/10171/20434 | - |
dc.description.abstract | PURPOSE: The purpose of this research was to identify promiscuous T-helper cell determinants (THd) from carcinoembryonic antigen (CEA) to be used to prime T-cell help for cancer therapy. CEA was selected because this antigen is expressed in an important variety of carcinomas. EXPERIMENTAL DESIGN: Potential promiscuous THd from CEA were predicted using available computer algorithms. Predicted peptides were synthesized and tested in binding experiments to different HLA-DR molecules. Binder peptides were then used to prime T-cell responses both in vitro and in vivo. RESULTS: Twenty 15-mer peptides from CEA were predicted to bind to different HLA-DR molecules. The promiscuous character of these peptides was demonstrated in binding experiments. Fifteen of 20 peptides tested were able to bind to HLA-DR4, but only CEA (625-639) was shown to be presented after processing of recombinant CEA. CEA (625-639) was also found to be presented by HLA-DR53. Moreover, immunization of HLA-DR4 transgenic mice with CEA (625-639) in conjunction with class I epitope OVA (257-264), induced a CTL response specific of OVA (257-264). CONCLUSIONS: CEA (625-639) might be a relevant promiscuous THd peptide for cancer therapy. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American association for cancer research | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Carcinoembryonic Antigen/chemistry | es_ES |
dc.subject | Carcinoembryonic Antigen/immunology | es_ES |
dc.subject | Peptides/chemistry | es_ES |
dc.subject | T-Lymphocytes, Helper-Inducer/chemistry | es_ES |
dc.title | Identification and characterization of a T-helper peptide from carcinoembryonic antigen | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1158/1078-0432.CCR-03-0476 | es_ES |
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