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dc.creatorHuarte, E. (Eduardo)-
dc.creatorSarobe, P. (Pablo)-
dc.creatorLasarte, J.J. (Juan José)-
dc.creatorBrem, G. (Gottfried)-
dc.creatorWeiss, E. (Elisabeth)-
dc.creatorPrieto, J. (Jesús)-
dc.creatorBorras-Cuesta, F. (Francisco)-
dc.date.accessioned2012-01-26T16:56:39Z-
dc.date.available2012-01-26T16:56:39Z-
dc.date.issued2002-
dc.identifier.citationHuarte E, Sarobe P, Lasarte JJ, Brem G, Weiss EH, Prieto J, et al. Identification of HLA-B27-restricted cytotoxic T lymphocyte epitope from carcinoembryonic antigen. Int J Cancer 2002 Jan 1;97(1):58-63.es_ES
dc.identifier.isbn0020-7136-
dc.identifier.urihttp://hdl.handle.net/10171/20621-
dc.description.abstractCharacterization of epitopes recognized by cytotoxic T lymphocytes (CTLs) in the sequence of tumor antigens is an important step in the development of tumor therapies. Because carcinoembryonic antigen (CEA) is a protein expressed in a high number of epithelial tumors, it is an interesting target to study. We screened for the presence of HLA-B27-restricted CTL epitopes from CEA by studying the binding to HLA-B27 of 31 synthetic peptides predicted to bind to this molecule. This afforded 16 peptides with moderate or high binding affinity. Immunization of HLA-B27 transgenic mice with the best binder peptides yielded 4 immunogenic peptides: CEA(9-17), CEA(9-18), CEA(138-146) and CEA(360-369). However, splenocytes from mice immunized with a vaccinia virus-expressing CEA recognized only CEA(9-18). These CTLs were of the CD8(+) phenotype, which upon stimulation with peptide specifically produced IFN-gamma. Moreover, they did not cross-react against peptides of region 9-18 from proteins of the CEA family. Our results show that CEA(9-18) may induce specific CTL responses against CEA.es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.rightsinfo:eu-repo/semantics/closedAccess-
dc.subjectCytotoxic T lymphocytees_ES
dc.subjectCarcinoembryonic antigenes_ES
dc.subjectHLA-B27es_ES
dc.subjectPeptideses_ES
dc.subjectTumores_ES
dc.titleIdentification of HLA-B27-restricted cytotoxic T lymphocyte epitope from carcinoembryonic antigenes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1002/ijc.1579es_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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