Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Huarte, E. (Eduardo) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Brem, G. (Gottfried) | - |
dc.creator | Weiss, E. (Elisabeth) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.date.accessioned | 2012-01-26T16:56:39Z | - |
dc.date.available | 2012-01-26T16:56:39Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Huarte E, Sarobe P, Lasarte JJ, Brem G, Weiss EH, Prieto J, et al. Identification of HLA-B27-restricted cytotoxic T lymphocyte epitope from carcinoembryonic antigen. Int J Cancer 2002 Jan 1;97(1):58-63. | es_ES |
dc.identifier.isbn | 0020-7136 | - |
dc.identifier.uri | https://hdl.handle.net/10171/20621 | - |
dc.description.abstract | Characterization of epitopes recognized by cytotoxic T lymphocytes (CTLs) in the sequence of tumor antigens is an important step in the development of tumor therapies. Because carcinoembryonic antigen (CEA) is a protein expressed in a high number of epithelial tumors, it is an interesting target to study. We screened for the presence of HLA-B27-restricted CTL epitopes from CEA by studying the binding to HLA-B27 of 31 synthetic peptides predicted to bind to this molecule. This afforded 16 peptides with moderate or high binding affinity. Immunization of HLA-B27 transgenic mice with the best binder peptides yielded 4 immunogenic peptides: CEA(9-17), CEA(9-18), CEA(138-146) and CEA(360-369). However, splenocytes from mice immunized with a vaccinia virus-expressing CEA recognized only CEA(9-18). These CTLs were of the CD8(+) phenotype, which upon stimulation with peptide specifically produced IFN-gamma. Moreover, they did not cross-react against peptides of region 9-18 from proteins of the CEA family. Our results show that CEA(9-18) may induce specific CTL responses against CEA. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Cytotoxic T lymphocyte | es_ES |
dc.subject | Carcinoembryonic antigen | es_ES |
dc.subject | HLA-B27 | es_ES |
dc.subject | Peptides | es_ES |
dc.subject | Tumor | es_ES |
dc.title | Identification of HLA-B27-restricted cytotoxic T lymphocyte epitope from carcinoembryonic antigen | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1002/ijc.1579 | es_ES |
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