Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Lopez-Sanchez, L.M. (Laura M.) | - |
dc.creator | Collado, J.A. (Juan A.) | - |
dc.creator | Corrales, F.J. (Fernando José) | - |
dc.creator | Lopez-Cillero, P. (Pedro) | - |
dc.creator | Montero, J.L. (José L.) | - |
dc.creator | Fraga, E. (Enrique) | - |
dc.creator | Serrano, J. (Juan) | - |
dc.creator | Mata, M. (Manuel) de la | - |
dc.creator | Muntane, J. (Jordi) | - |
dc.creator | Rodriguez-Ariza, A. (Antonio) | - |
dc.date.accessioned | 2012-04-02T07:49:26Z | - |
dc.date.available | 2012-04-02T07:49:26Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Lopez-Sanchez LM, Collado JA, Corrales FJ, Lopez-Cillero P, Montero JL, Fraga E, et al. S-Nitrosation of proteins during D-galactosamine-induced cell death in human hepatocytes. Free Radic Res 2007 Jan;41(1):50-61. | es_ES |
dc.identifier.issn | 1029-2470 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21476 | - |
dc.description.abstract | Nitric oxide (NO) participates in the cell death induced by d-Galactosamine (d-GalN) in hepatocytes, and NO-derived reactive oxygen intermediates are critical contributors to protein modification and hepatocellular injury. It is anticipated that S-nitrosation of proteins will participate in the mechanisms leading to cell death in d-GalN-treated human hepatocytes. In the present study, d-GalN-induced cell death was related to augmented levels of NO production and S-nitrosothiol (SNO) content. The biotin switch assay confirmed that d-GalN increased the levels of S-nitrosated proteins in human hepatocytes. S-nitrosocysteine (CSNO) enhanced protein S-nitrosation and altered cell death parameters that were related to S-nitrosation of the executioner caspase-3. Fifteen S-nitrosated proteins participating in metabolism, antioxidative defense and cellular homeostasis were identified in human hepatocytes treated with CSNO. Among them, seven were also identified in d-GalN-treated hepatocytes. The results here reported underline the importance of the alteration of SNO homeostasis during d-GalN-induced cell death in human hepatocytes | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Informa Healthcare | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Hepatocyte | es_ES |
dc.subject | d-Galactosamine | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Necrosis | es_ES |
dc.subject | S-nitrosation | es_ES |
dc.subject | Proteomics | es_ES |
dc.title | S-Nitrosation of proteins during D-galactosamine-induced cell death in human hepatocytes | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://informahealthcare.com/doi/abs/10.1080/10715760600943918 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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