Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Martinez-Chantar, M.L. (María Luz) | - |
dc.creator | Ruiz Garcia-Trevijano, E. (Elena) | - |
dc.creator | Latasa, M.U. (María Ujué) | - |
dc.creator | Perez-Mato, I. (Isabel) | - |
dc.creator | Sanchez-del-Pino, M.M. (Manuel M.) | - |
dc.creator | Corrales, F.J. (Fernando José) | - |
dc.creator | Avila, M.A. (Matías Antonio) | - |
dc.creator | Mato, J.M. (José María) | - |
dc.date.accessioned | 2012-04-02T07:50:08Z | - |
dc.date.available | 2012-04-02T07:50:08Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Martinez-Chantar ML, Garcia-Trevijano ER, Latasa MU, Perez-Mato I, Sanchez del Pino MM, Corrales FJ, et al. Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury. Am J Clin Nutr 2002 Nov;76(5):1177S-82S. | es_ES |
dc.identifier.issn | 1938-3207 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21479 | - |
dc.description.abstract | One of the features of liver cirrhosis is an abnormal metabolism of methionine--a characteristic that was described more than a half a century ago. Thus, after an oral load of methionine, the rate of clearance of this amino acid from the blood is markedly impaired in cirrhotic patients compared with that in control subjects. Almost 15 y ago we observed that the failure to metabolize methionine in cirrhosis was due to an abnormally low activity of the enzyme methionine adenosyltransferase (EC 2.5.1.6). This enzyme converts methionine, in the presence of ATP, to S-adenosyl-L-methionine (SAMe), the main biological methyl donor. Since then, it has been suspected that a deficiency in hepatic SAMe may contribute to the pathogenesis of the liver in cirrhosis. The studies reviewed here are consistent with this hypothesis. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Nutrition | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Methionine | es_ES |
dc.subject | S-adenosyl-l-methionine | es_ES |
dc.subject | SAMe | es_ES |
dc.subject | Methionine adenosyltransferase | es_ES |
dc.subject | Liver injury | es_ES |
dc.subject | Liver regeneration | es_ES |
dc.subject | Cirrhosis | es_ES |
dc.subject | Oxidative stress | es_ES |
dc.subject | Protein S-nitrosylation | es_ES |
dc.title | Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.ajcn.org/content/76/5/1177S | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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