Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Guruceaga, E. (Elizabeth) | - |
dc.creator | Segura, V. (Víctor) | - |
dc.creator | Corrales, F.J. (Fernando José) | - |
dc.creator | Rubio, A. (Ángel) | - |
dc.date.accessioned | 2012-04-02T07:50:58Z | - |
dc.date.available | 2012-04-02T07:50:58Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Guruceaga E, Segura V, Corrales FJ, Rubio A. Genome-wide proximal promoter analysis and interpretation. Methods Mol Biol 2010;593:157-174. | es_ES |
dc.identifier.issn | 1940-6029 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21483 | - |
dc.description.abstract | High-throughput gene expression technologies based on DNA microarrays allow the examination of biological systems. However, the interpretation of the complex molecular descriptions generated by these approaches is still challenging. The development of new methodologies to identify common regulatory mechanisms involved in the control of the expression of a set of co-expressed genes might enhance our capacity to extract functional information from genomic data sets. In this chapter, we describe a method that integrates different sources of information: gene expression data, genome sequence information, described transcription factor binding sites (TFBSs), functional information, and bibliographic data. The starting point of the analysis is the extraction of promoter sequences from a whole genome and the detection of TFBSs in each gene promoter. This information allows the identification of enriched TFBSs in the proximal promoter of differentially expressed genes. The functional and bibliographic interpretation of the results improves our biological insight into the regulatory mechanisms involved in a microarray experiment. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Humana Press | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Computational Biology/methods | es_ES |
dc.subject | Data Interpretation, Statistical | es_ES |
dc.subject | Genome, Human/genetics | es_ES |
dc.subject | Promoter Regions, Genetic | es_ES |
dc.title | Genome-wide proximal promoter analysis and interpretation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.springerlink.com/content/q624436t892625t6/#section=614821&page=1 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
Files in This Item:
There are no files associated with this item.
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.