Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Golvano, J.J. (José Javier) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Gullon, A. (Arturo) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.date.accessioned | 2012-04-04T09:43:27Z | - |
dc.date.available | 2012-04-04T09:43:27Z | - |
dc.date.issued | 1990 | - |
dc.identifier.citation | Golvano J, Lasarte JJ, Sarobe P, Gullon A, Prieto J, Borras-Cuesta F. Polarity of immunogens: implications for vaccine design. Eur J Immunol 1990 Oct;20(10):2363-2366. | es_ES |
dc.identifier.issn | 1521-4141 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21596 | - |
dc.description.abstract | Peptide constructs have been engineered consisting of amino acid sequence determinant recognized by T cells (TD) co-linearly linked to haptenic peptides. It was found that high anti-hapten antibody titers were induced after immunization with those constructs which had the TD sequence in the N-terminal position with respect to the hapten. Low or zero titers were elicited when the TD was in C-terminal position. Also, a high anti-hapten antibody titer corresponded to a low or zero anti-TD antibody titer and vice versa. These results suggest that immunogens are polar and stress the relevance of searching the more adequate position of the TD within a peptide construct when designing immunogens or synthetic peptide vaccines. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-VCH Verlag Berlin | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Antigens/immunology | es_ES |
dc.subject | Vaccines, Synthetic/immunology | es_ES |
dc.title | Polarity of immunogens: implications for vaccine design | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/eji.1830201031/abstract | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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