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dc.creatorKobayashi, H. (Hiroya)-
dc.creatorOmiya, R. (Ryusuke)-
dc.creatorRuiz, M. (Marta)-
dc.creatorHuarte, E. (Eduardo)-
dc.creatorSarobe, P. (Pablo)-
dc.creatorLasarte, J.J. (Juan José)-
dc.creatorHerraiz-Bayod, M.J. (Maite J.)-
dc.creatorSangro, B. (Bruno)-
dc.creatorPrieto, J. (Jesús)-
dc.creatorBorras-Cuesta, F. (Francisco)-
dc.creatorCelis, E. (Esteban)-
dc.identifier.citationKobayashi H, Omiya R, Ruiz M, Huarte E, Sarobe P, Lasarte JJ, et al. Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen. Clin Cancer Res 2002 Oct;8(10):3219-3225.es_ES
dc.description.abstractPURPOSE: The product of the carcinoembryonic antigen (CEA) gene is an attractive candidate for T-cell-based immunotherapy because it is frequently expressed in epithelial solid carcinomas. Although many CEA peptide epitopes capable of stimulating CTLs have been identified, no MHC class II-restricted T helper epitope has yet been reported. Experimental Design: The amino acid sequence of CEA was examined for the presence of potential T helper epitopes, and candidate peptides were used to stimulate in vitro T-cell responses. RESULTS: We describe here that using an algorithm to identify promiscuous helper T-cell epitopes, a peptide of CEA occupying residue positions 653 to 667 (CEA(653-667)), was effective in inducing in vitro T helper responses in the context of the HLA-DR4, HLA-DR7, and HLA-DR 9 alleles. Most significantly, some of the peptide-reactive helper T lymphocytes were also capable of recognizing naturally processed antigen in the form of recombinant CEA protein or cell lysates from tumors that express CEA. Interestingly, the newly identified helper T-cell epitope was found to overlap with a previously described HLA-A24-restricted CTL epitope, CEA(652-660), which could facilitate the development of a therapeutic vaccine capable of eliciting both CTL and T helper responses in patients suffering from epithelial carcinomas. CONCLUSION: These results indicate that T helper lymphocytes are capable of recognizing CEA as a tumor antigen and that epitope CEA(653-667) could be used for immunotherapy against tumors expressing CEA.es_ES
dc.publisherAmerican Association for Cancer Researches_ES
dc.subjectCarcinoembryonic Antigen/immunologyes_ES
dc.subjectColonic Neoplasms/immunologyes_ES
dc.subjectEpitopes, T-Lymphocyte/immunologyes_ES
dc.subjectLymphoma, T-Cell/immunologyes_ES
dc.subjectT-Lymphocytes, Cytotoxic/immunologyes_ES
dc.subjectT-Lymphocytes, Helper-Inducer/immunologyes_ES
dc.titleIdentification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigenes_ES

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