Full metadata record
DC Field | Value | Language |
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dc.creator | Kobayashi, H. (Hiroya) | - |
dc.creator | Omiya, R. (Ryusuke) | - |
dc.creator | Ruiz, M. (Marta) | - |
dc.creator | Huarte, E. (Eduardo) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Herraiz-Bayod, M.J. (Maite J.) | - |
dc.creator | Sangro, B. (Bruno) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.creator | Celis, E. (Esteban) | - |
dc.date.accessioned | 2012-04-04T12:16:20Z | - |
dc.date.available | 2012-04-04T12:16:20Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Kobayashi H, Omiya R, Ruiz M, Huarte E, Sarobe P, Lasarte JJ, et al. Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen. Clin Cancer Res 2002 Oct;8(10):3219-3225. | es_ES |
dc.identifier.issn | 1557-3265 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21600 | - |
dc.description.abstract | PURPOSE: The product of the carcinoembryonic antigen (CEA) gene is an attractive candidate for T-cell-based immunotherapy because it is frequently expressed in epithelial solid carcinomas. Although many CEA peptide epitopes capable of stimulating CTLs have been identified, no MHC class II-restricted T helper epitope has yet been reported. Experimental Design: The amino acid sequence of CEA was examined for the presence of potential T helper epitopes, and candidate peptides were used to stimulate in vitro T-cell responses. RESULTS: We describe here that using an algorithm to identify promiscuous helper T-cell epitopes, a peptide of CEA occupying residue positions 653 to 667 (CEA(653-667)), was effective in inducing in vitro T helper responses in the context of the HLA-DR4, HLA-DR7, and HLA-DR 9 alleles. Most significantly, some of the peptide-reactive helper T lymphocytes were also capable of recognizing naturally processed antigen in the form of recombinant CEA protein or cell lysates from tumors that express CEA. Interestingly, the newly identified helper T-cell epitope was found to overlap with a previously described HLA-A24-restricted CTL epitope, CEA(652-660), which could facilitate the development of a therapeutic vaccine capable of eliciting both CTL and T helper responses in patients suffering from epithelial carcinomas. CONCLUSION: These results indicate that T helper lymphocytes are capable of recognizing CEA as a tumor antigen and that epitope CEA(653-667) could be used for immunotherapy against tumors expressing CEA. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Association for Cancer Research | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Carcinoembryonic Antigen/immunology | es_ES |
dc.subject | Colonic Neoplasms/immunology | es_ES |
dc.subject | Epitopes, T-Lymphocyte/immunology | es_ES |
dc.subject | Lymphoma, T-Cell/immunology | es_ES |
dc.subject | T-Lymphocytes, Cytotoxic/immunology | es_ES |
dc.subject | T-Lymphocytes, Helper-Inducer/immunology | es_ES |
dc.title | Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://clincancerres.aacrjournals.org/content/8/10/3219 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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