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dc.creatorLarrea, E. (Esther)-
dc.creatorAixalá, Jaime. El mistico serafin de la Menor Regular Clerencia, exaltado al sacratisimo trono de los altares ...-
dc.creatorGonzalez, I. (Iranzu)-
dc.creatorSegura, V. (Víctor)-
dc.creatorSarobe, P. (Pablo)-
dc.creatorEcheverria, I. (Itziar)-
dc.creatorPrieto, J. (Jesús)-
dc.identifier.citationLarrea E, Aldabe R, Gonzalez I, Segura V, Sarobe P, Echeverria I, et al. Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells. J Virol 2009 Apr;83(7):3298-3311.es_ES
dc.description.abstractOncostatin M (OSM) is released together with type I interferon (IFN) by activated dendritic cells, suggesting a concerted action of these cytokines in the biological response against infection. We found that OSM increases the antiviral effect of IFN-alpha in Huh7 hepatoma cells infected with hepatitis A or hepatitis C virus and synergizes with IFN-alpha in the induction of antiviral genes. The combination of OSM and IFN-alpha led to upregulation of both STAT1 and STAT3 together with intense and prolonged activation of STAT1, STAT3, and Jak1. OSM with or without IFN-alpha also activated p38 mitogen-activated protein kinase, which is known to enhance transcription of IFN-alpha-inducible genes. Interestingly, OSM combined with IFN-alpha strongly induced immunoproteasome genes and other genes involved in antigen processing and presentation. Moreover, OSM, alone or in combination with IFN-alpha, upregulated relevant innate immunity molecules and increased the expression of intracellular adhesion molecule 1 and interleukin-15 receptor alpha (IL-15Ralpha) in liver cells. Hepatoma cells transfected with a plasmid encoding a viral antigen were able to activate effector T cells when pretreated with IFN-alpha plus OSM but not with each cytokine separately. Also, OSM, more than IFN-alpha, augmented the ability of Huh7 cells to transpresent IL-15 to responding lymphocytes and increased the immunostimulatory activity of liver epithelial cells by presenting a short viral peptide to sensitized cytotoxic T cells. In conclusion, OSM enhances the antiviral effects of type I interferon and cooperates with it in the induction of adaptive immune responses to pathogens. These findings may have therapeutic implications.es_ES
dc.publisherAmerican Society for Microbiologyes_ES
dc.subjectEpithelial Cells/immunologyes_ES
dc.subjectHepatitis A virus/immunologyes_ES
dc.subjectInterferon Type I/immunologyes_ES
dc.subjectOncostatin M/immunologyes_ES
dc.titleOncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cellses_ES

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