Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection
Palabras clave : 
Gene Expression Regulation, Enzymologic
Hepatitis C/enzymology
Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism
Fecha incorporación: 
2007
Editorial : 
American Society for Microbiology
ISSN: 
1098-5514
Cita: 
Larrea E, Riezu-Boj JI, Gil-Guerrero L, Casares N, Aldabe R, Sarobe P, et al. Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection. J Virol 2007 Apr;81(7):3662-3666.
Resumen
Indoleamine 2,3-dioxygenase (IDO) is induced by proinflammatory cytokines and by CTLA-4-expressing T cells and constitutes an important mediator of peripheral immune tolerance. In chronic hepatitis C, we found upregulation of IDO expression in the liver and an increased serum kynurenine/tryptophan ratio (a reflection of IDO activity). Huh7 cells supporting hepatitis C virus (HCV) replication expressed higher levels of IDO mRNA than noninfected cells when stimulated with gamma interferon or when cocultured with activated T cells. In infected chimpanzees, hepatic IDO expression decreased in animals that cured the infection, while it remained high in those that progressed to chronicity. For both patients and chimpanzees, hepatic expression of IDO and CTLA-4 correlated directly. Induction of IDO may dampen T-cell reactivity to viral antigens in chronic HCV infection

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Fichero: 
JVirol2007_3662.pdf
Descripción: 
Tamaño: 
315,54 kB
Formato: 
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