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dc.creatorMerino, I. (Isidro)-
dc.creatorMonge, A. (Antonio)-
dc.creatorFont, M. (María)-
dc.creatorMartinez-de-Irujo, J.J. (Juan José)-
dc.creatorAlberdi, E. (Elena)-
dc.creatorSantiago, E. (Esteban)-
dc.creatorPrieto, I. (Isidro)-
dc.creatorLasarte, J.J. (Juan José)-
dc.creatorSarobe, P. (Pablo)-
dc.creatorBorras-Cuesta, F. (Francisco)-
dc.date.accessioned2012-04-13T15:19:55Z-
dc.date.available2012-04-13T15:19:55Z-
dc.date.issued1999-
dc.identifier.citationI, Monge A, Font M, Martinez de Irujo JJ, Alberdi E, Santiago E, et al. Synthesis and anti-HIV-1 activities of new pyrimido[5,4-b]indoles. Farmaco 1999 Apr 30;54(4):255-264.es_ES
dc.identifier.issn0014-827X-
dc.identifier.urihttp://hdl.handle.net/10171/21652-
dc.description.abstractA set of new pyrimido[5,4-b]indole derivatives that are structurally related to some non-nucleside HIV-1 reverse transcriptase inhibitors were synthesized and biologically evaluated for their activity as inhibitors of wild and mutant HIV-1 RT types in an 'in vitro' recombinant HIV-1 RT screening assay, as well as anti-infectives in HLT4lacZ-1IIIB cells. Preliminary structure-activity relationships suggest that activity is promoted by simultaneous substitution in positions 2 and 4, especially when chains of alkyldiamine type are present, and by electron-releasing substituents (methoxy) in positions 7 and 8. The inactivity or the very low activity of title derivatives does not suggest interest in AIDS therapy.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectPyrimido[5,4-b]indoleses_ES
dc.subjectHIV-1 RT inhibitorses_ES
dc.subjectHLT4lacZ-1IIIB cellses_ES
dc.titleSynthesis and anti-HIV-1 activities of new pyrimido[5,4-b]indoleses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0014827X9900035Xes_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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