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DC Field | Value | Language |
---|---|---|
dc.creator | Merino, I. (Isidro) | - |
dc.creator | Monge, A. (Antonio) | - |
dc.creator | Font, M. (María) | - |
dc.creator | Martinez-de-Irujo, J.J. (Juan José) | - |
dc.creator | Alberdi, E. (Elena) | - |
dc.creator | Santiago, E. (Esteban) | - |
dc.creator | Prieto, I. (Isidro) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.date.accessioned | 2012-04-13T15:19:55Z | - |
dc.date.available | 2012-04-13T15:19:55Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | I, Monge A, Font M, Martinez de Irujo JJ, Alberdi E, Santiago E, et al. Synthesis and anti-HIV-1 activities of new pyrimido[5,4-b]indoles. Farmaco 1999 Apr 30;54(4):255-264. | es_ES |
dc.identifier.issn | 0014-827X | - |
dc.identifier.uri | https://hdl.handle.net/10171/21652 | - |
dc.description.abstract | A set of new pyrimido[5,4-b]indole derivatives that are structurally related to some non-nucleside HIV-1 reverse transcriptase inhibitors were synthesized and biologically evaluated for their activity as inhibitors of wild and mutant HIV-1 RT types in an 'in vitro' recombinant HIV-1 RT screening assay, as well as anti-infectives in HLT4lacZ-1IIIB cells. Preliminary structure-activity relationships suggest that activity is promoted by simultaneous substitution in positions 2 and 4, especially when chains of alkyldiamine type are present, and by electron-releasing substituents (methoxy) in positions 7 and 8. The inactivity or the very low activity of title derivatives does not suggest interest in AIDS therapy. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Pyrimido[5,4-b]indoles | es_ES |
dc.subject | HIV-1 RT inhibitors | es_ES |
dc.subject | HLT4lacZ-1IIIB cells | es_ES |
dc.title | Synthesis and anti-HIV-1 activities of new pyrimido[5,4-b]indoles | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0014827X9900035X | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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