Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Golvano, J.J. (José Javier) | - |
dc.creator | Prieto, I. (Isidro) | - |
dc.creator | Civeira, M.P. (María Pilar) | - |
dc.creator | Gullon, A. (Arturo) | - |
dc.creator | Sarin, P.S. (Prem S.) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.date.accessioned | 2012-04-13T15:20:28Z | - |
dc.date.available | 2012-04-13T15:20:28Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Lasarte JJ, Sarobe P, Golvano J, Prieto I, Civeira MP, Gullon A, et al. CD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitro. J Acquir Immune Defic Syndr 1994 Feb;7(2):129-134. | es_ES |
dc.identifier.issn | 1944-7884 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21653 | - |
dc.description.abstract | Phenylalanine-containing peptides from CD4 were synthesized based on chemical similarity with active CD4(81-92)-benzylated peptides. The synthetic peptide FYIFFVEDQKEEDD blocked the binding of gp120 to CD4 and inhibited 50% human immunodeficiency virus (HIV)-induced syncytia formation at a concentration (IC50) of approximately 40-50 microM and HIV p17 expression with an IC50 of approximately 67 microM. The peptide is not toxic to cells in vitro. Moreover, acute toxicity studies carried out in Swiss mice showed the peptide to be nontoxic at a dose of 2,000 mg/kg. This phenylalanine-substituted CD4 peptide may prove to be useful in the treatment of AIDS. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott, Williams & Wilkins | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | HIV-1/drug effects | es_ES |
dc.subject | Peptides/pharmacology | es_ES |
dc.subject | Phenylalanine/chemistry | es_ES |
dc.subject | Viral Proteins | es_ES |
dc.title | CD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitro | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://bit.ly/HeCxzF | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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