Full metadata record
DC FieldValueLanguage
dc.creatorLasarte, J.J. (Juan José)-
dc.creatorSarobe, P. (Pablo)-
dc.creatorGullon, A. (Arturo)-
dc.creatorPrieto, J. (Jesús)-
dc.creatorBorras-Cuesta, F. (Francisco)-
dc.date.accessioned2012-04-16T08:34:15Z-
dc.date.available2012-04-16T08:34:15Z-
dc.date.issued1992-
dc.identifier.citationLasarte JJ, Sarobe P, Gullon A, Prieto J, Borras-Cuesta F. Induction of cytotoxic T lymphocytes in mice against the principal neutralizing domain of HIV-1 by immunization with an engineered T-cytotoxic-T-helper synthetic peptide construct. Cell Immunol 1992 Apr 15;141(1):211-218.es_ES
dc.identifier.issn1090-2163-
dc.identifier.urihttp://hdl.handle.net/10171/21654-
dc.description.abstractPeptide constructs were engineered by colinear synthesis of two short synthetic peptide determinants; a determinant recognized by T helper cells (TDh) and a determinant recognized by T cytotoxic cells (TDc). Three types of constructs were synthesized: TDc-TDh, TDh-TDc, and TDh-KK-TDc, where KK are two lysine residues. In vivo immunization with free construct induced cytolytic lymphocytes (CTL) only in the case of TDc-TDh. However, immunization with spleen cells to which these constructs had been internalized by hypertonic shock, induced CTL activity in all three cases. No CTL could be induced after immunization with free TDc in either protocol. These results indicate that cell internalization of the construct might be essential for CTL induction, and also, that "help" from the TDh seems to be required.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectHIV Antigens/immunologyes_ES
dc.subjectHIV-1/immunologyes_ES
dc.subjectPeptides/immunologyes_ES
dc.subjectT-Lymphocytes, Cytotoxic/immunologyes_ES
dc.subjectT-Lymphocytes, Helper-Inducer/immunologyes_ES
dc.titleInduction of cytotoxic T lymphocytes in mice against the principal neutralizing domain of HIV-1 by immunization with an engineered T-cytotoxic-T-helper synthetic peptide constructes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/000887499290140Kes_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

Files in This Item:
File: 
CellImmunol1992141211.pdf
Description: 
Size: 
569,29 kB
Format: 
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.