Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Larrea, E. (Esther) | - |
dc.creator | Golvano, J.J. (José Javier) | - |
dc.creator | Prieto, I. (Inés) | - |
dc.creator | Gullon, A. (Arturo) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.date.accessioned | 2012-04-17T14:15:43Z | - |
dc.date.available | 2012-04-17T14:15:43Z | - |
dc.date.issued | 1993 | - |
dc.identifier.citation | Sarobe P, Lasarte JJ, Larrea E, Golvano JJ, Prieto I, Gullon A, et al. Enhancement of peptide immunogenicity by insertion of a cathepsin B cleavage site between determinants recognized by B and T cells. Res Immunol 1993 May;144(4):257-262. | es_ES |
dc.identifier.issn | 0923-2494 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21660 | - |
dc.description.abstract | The insertion of two lysine residues (cleavage sites of cathepsin B) at the boundary of a peptide recognized by B cells (BD) and a class-II- presentable sequence (TDh) enhanced the anti-BD antibody induction capacity of this type of peptide construct, as well as production of IL2. It is postulated that these lysines generate a neoprocessable site which helps in release of the TDh moiety from the construct, enabling its presentation to class II molecules, an essential step in clonal expansion of the antibody-producing B cell after internalization of the construct via the BD moiety. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Immunogenicity | es_ES |
dc.subject | Peptide | es_ES |
dc.subject | Lysine | es_ES |
dc.subject | B cell | es_ES |
dc.subject | T cell | es_ES |
dc.subject | IL2 | es_ES |
dc.subject | Determinant | es_ES |
dc.subject | Cathepsin B | es_ES |
dc.subject | Antigen processing | es_ES |
dc.title | Enhancement of peptide immunogenicity by insertion of a cathepsin B cleavage site between determinants recognized by B and T cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/0923249493801025 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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