Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Okazaki, T. (Takahiro) | - |
dc.creator | Pendleton, C.D. (C. David) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Thomas, E.K. (Elaine K.) | - |
dc.creator | Iyengar, S. (Sujatha) | - |
dc.creator | Harro, C. (Clayton) | - |
dc.creator | Schwartz, D. (David) | - |
dc.creator | Berzofsky, J.A. (Jay A.) | - |
dc.date.accessioned | 2012-04-17T14:18:03Z | - |
dc.date.available | 2012-04-17T14:18:03Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Okazaki T, Pendleton CD, Sarobe P, Thomas EK, Iyengar S, Harro C, et al. Epitope enhancement of a CD4 HIV epitope toward the development of the next generation HIV vaccine. J Immunol 2006 Mar 15;176(6):3753-3759. | es_ES |
dc.identifier.issn | 1550-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21664 | - |
dc.description.abstract | Virus-specific CD4+ T cell help and CD8+ cytotoxic T cell responses are critical for maintenance of effective immunity in chronic viral infections. The importance of CD4+ T cells has been documented in HIV infection. To investigate whether a stronger CD4+ T cell response can be induced by modifications to enhance the T1 epitope, the first CD4+ T cell epitope discovered in HIV-1-gp120, we developed a T1-specific CD4+ T cell line from a healthy volunteer immunized with a canarypox vector expressing gp120 and boosted with recombinant gp120. This T1-specific CD4+ T cell line was restricted to DR13, which is common in U.S. Caucasians and African-Americans and very frequent in Africans. Peptides with certain amino acid substitutions in key positions induced enhanced specific CD4+ T cell proliferative responses at lower peptide concentration than the original epitope. This relatively conserved CD4 epitope improved by the epitope enhancement strategy could be a component of a more effective second generation vaccine construct for HIV infection. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Association of Immunologists | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | AIDS Vaccines/chemistry | es_ES |
dc.subject | AIDS Vaccines/immunology | es_ES |
dc.subject | CD4-Positive T-Lymphocytes/immunology | es_ES |
dc.subject | Epitopes, T-Lymphocyte/chemistry | es_ES |
dc.subject | Epitopes, T-Lymphocyte/immunology | es_ES |
dc.subject | HIV-1/immunology | es_ES |
dc.title | Epitope enhancement of a CD4 HIV epitope toward the development of the next generation HIV vaccine | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.jimmunol.org/content/176/6/3753 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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