(Institución)/></a>
				</td>
				<td class= (Institución)
   (Nuevo usuario)
Ayuda  | Contacto  |  Castellano English  
 

Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología hepatitis virales > DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista >

A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury
Autor(es) : Ezquerro, I.J. (Ignacio José)
Lasarte, J.J. (Juan José)
Dotor, J. (Javier)
Castilla-Cortazar, I. (Inma)
Bustos, M. (Matilde)
Peñuelas, I. (Iván)
Blanco, G. (Gemma)
Rodriguez-Ortigosa, C.M. (Carlos M.)
Lechuga, M.C.G. (María del Carmen G.)
Greenwel, P. (Patricia)
Rojkind, M. (Marcos)
Prieto, J. (Jesús)
Borras-Cuesta, F. (Francisco)
Palabras clave : Collagen
Flow cytometry
Hepatic stellate cells
Liver cirrhosis
MV1Lu cells
Fecha incorporación: 2003
Editorial : Elsevier
Versión del editor: http://www.sciencedirect.com/science/article/pii/S1043466603001017
ISSN: 1096-0023
Cita: Ezquerro IJ, Lasarte JJ, Dotor J, Castilla-Cortazar I, Bustos M, Penuelas I, et al. A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine 2003 Apr;22(1-2):12-20.
Resumen
Transforming growth factor beta1 (TGF-beta1) is a pleiotropic cytokine, which displays potent profibrogenic effects and is highly expressed in fibrotic livers. For this reason, development of TGF-B1 inhibitors might be of great importance to control liver fibrogenesis as well as other undesired side effects due to this cytokine. Potential peptide inhibitors of TGF-beta1 (derived from TGF-beta1 and from its type III receptor) were tested in vitro and in vivo using different assays. Peptides P11 and P12, derived from TGF-beta1, and P54 and P144, derived from its type III receptor, prevented TGF-beta1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduced binding of TGF-beta1 to its receptors. P144 blocked TGF-beta1-dependent stimulation of a reporter gene under the control of human alpha2(I) collagen promoter. Intraperitoneal administration of P144 also showed potent antifibrogenic activity in vivo in the liver of rats receiving CCl4. These rats also showed a significant decrease in the number of activated hepatic stellate cells as compared with those treated with saline only. These results suggest that short synthetic peptides derived from TGF-beta1 type III receptor may be of value in reducing liver fibrosis in chronic liver injury.
Enlace permanente: http://hdl.handle.net/10171/21673
Aparece en las colecciones: DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista

Ficheros en este registro:
Fichero:  Cytokine20032212.pdf
Descripción: 
Tamaño:  3,41 MB
Formato:  Adobe PDF
 Visualizar / Abrir 

Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.