Full metadata record
DC FieldValueLanguage
dc.creatorGavier, B. (B.)-
dc.creatorMartinez-Gonzalez, M.A. (Miguel Ángel)-
dc.creatorRiezu-Boj, J.I. (José Ignacio)-
dc.creatorLasarte, J.J. (Juan José)-
dc.creatorGarcia, N. (Nicolás)-
dc.creatorCiveira, M.P. (María Pilar)-
dc.creatorPrieto, J. (Jesús)-
dc.date.accessioned2012-04-17T14:41:24Z-
dc.date.available2012-04-17T14:41:24Z-
dc.date.issued1997-
dc.identifier.citationGavier B, Martinez-Gonzalez MA, Riezu-Boj JI, Lasarte JJ, Garcia N, Civeira MP, et al. Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C. Gastroenterology 1997 Nov;113(5):1647-1653.es_ES
dc.identifier.issn1528-0012-
dc.identifier.urihttps://hdl.handle.net/10171/21677-
dc.description.abstractBACKGROUND &#38; AIMS: In chronic hepatitis C, interferon alfa induces sustained remission in less than 30% of treated patients. The aim of this study is to analyze viral status early after initiation interferon therapy as a predictor of treatment outcome. METHODS: One hundred eighty-one patients with chronic hepatitis C who had been treated with interferon alfa for 12 months (median follow-up, 49 months) were studied. Viremia and aminotransferase levels at the first and third months of therapy as well as 10 pretreatment variables were assessed as potential independent predictors of sustained response to treatment. RESULTS: Sustained response occurred in 51 patients (28%). At month 1 of treatment, viral persistence accurately predicted nonresponse (predictive value, 95.3; 95% confidence interval, 86.0-98.8; P < 0.0001). Independent predictors of sustained response were undetectable viremia at the first month of therapy (P < 0.001), undetectable viremia at the third month (P < 0.001), younger age (P = 0.006), nonsporadic infection (P = 0.012), and higher pretreatment aspartate aminotransferase levels (P = 0.032). In patients who cleared HCV RNA at month 1 of therapy, the predicted probability of sustained response averaged 70% for those younger than 30 years and diminished by 10% for each decade of age. CONCLUSIONS: Failure to clear HCV RNA at month 1 of treatment is strongly and independently associated with a very low probability of a sustained response to interferon.es_ES
dc.language.isoenges_ES
dc.publisherWB Saunderses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAntiviral Agents/therapeutic usees_ES
dc.subjectHepatitis C/therapyes_ES
dc.subjectInterferon-alpha/therapeutic usees_ES
dc.subjectViremia/therapyes_ES
dc.titleViremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis Ces_ES
dc.typeArticuloes_ES
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0016508597005325es_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

Files in This Item:
Thumbnail
File
Gastroenterol19971131647.pdf
Description
Size
286.89 kB
Format
Adobe PDF


Statistics and impact
0 citas en
0 citas en

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.