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Liver transplantation in cirrhotic patients with diabetes mellitus: Midterm results, survival, and adverse events
Authors: Blanco, J.J. (Jose J.)
Herrero, J.I. (José Ignacio)
Quiroga, J. (Jorge)
Sangro, B. (Bruno)
Gomez-Manero, N. (Noemí)
Pardo, F. (Fernando)
Cienfuegos, J.A. (Javier A.)
Keywords: Liver Cirrhosis/complications/mortality/surgery
Liver transplantation
Diabetes complications
Issue Date: 2001
Publisher: Wiley-Blackwell
Publisher version:
ISSN: 1527-6465
Citation: Blanco JJ, Herrero JI, Quiroga J, Sangro B, Gomez-Manero N, Pardo F, et al. Liver transplantation in cirrhotic patients with diabetes mellitus: midterm results, survival, and adverse events. Liver Transpl 2001 Mar;7(3):226-233.
Liver cirrhosis is frequently associated with diabetes mellitus (DM), and this metabolic complication is also frequent after orthotopic liver transplantation (OLT). The aim of our study is to investigate which factors are associated with DM before and after OLT and their impact on post-OLT evolution. We evaluated the prevalence of DM among 115 liver transplant candidates with cirrhosis and assessed their evolution after OLT (median follow-up, 41 months). Sixteen candidates had DM requiring pharmacological therapy (group A), 45 candidates had DM controlled with diet (group B), and 54 candidates did not have DM (group C). One-year and 3-year actuarial survival rates were 100% and 100% for group A, 91% and 85% for group B, and 77% and 74% for group C, respectively (P <.03). Post-OLT DM was more frequent in group A. The incidence of other metabolic complications, major infections, rejection, and arterial hypertension; the need for hospitalization; and renal and graft function of patients in groups A, B, and C were similar. The only risk factor for DM 1 year after OLT on multivariate analysis was pre-OLT DM requiring pharmacological treatment. The incidence of complications, need for hospitalization, and renal and graft function 1 year after OLT for patients with post-OLT DM were similar to those of patients without post-OLT DM. In conclusion, patients with cirrhosis who have DM have a greater risk for post-OLT DM, but their midterm survival is not worse than the survival of those without DM.
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