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TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls
Authors: Ochoa, M.C. (María Carmen)
Moreno-Aliaga, M.J. (María Jesús)
Martinez-Gonzalez, M.A. (Miguel Ángel)
Martinez, J.A. (José Alfredo)
Marti, A. (Amelia)
Grupo de Estudio Navarro de la Obesidad Infantil (GENOI)
Keywords: ADRB2
Gln27Glu polymorphism
Obesity risk
Issue Date: 2006
Publisher: Informa Healthcare
Publisher version:
ISSN: 1747-7166
Citation: Ochoa MC, Moreno-Aliaga MJ, Martinez-Gonzalez MA, Martinez JA, Marti A, GENOI Members. TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls. Int J Pediatr Obes. 2006;1(2):83-8
OBJECTIVE: A matched case-control study was conducted in a population of Spanish children and adolescents (5-18 years old), to assess the interaction between the Gln27Glu polymorphism of the ADRB2 and television (TV) watching on obesity risk. PATIENTS: Obese (n=165) and control subjects (n=165) matched by sex and age were recruited and classified according to Spanish reference data. Results. Using conditional logistic regression, we calculated the obesity risk linked to the polymorphism. A statistically significant association was found for 27Glu carrier allele girls (OR = 1.95; 95% CI = 1.02-3.70), but no association was apparent among boys. In the fully adjusted model, the odds ratio for obesity linked to the genotype Glu27Glu in the female population rose to 4.84 (95% CI = 1.37-17.10). Moreover, we found a significant negative interaction between hours of TV watching and the Gln27Glu polymorphism for obesity risk in girls. Surprisingly, among 27Glu carrier subjects, even girls with a low level of TV watching ( < 12.5 h/week) had a high obesity risk (OR = 4.60; 95% CI = 1.01-20.02), which was not very different to the odds ratio values for sedentary girls carrying the 27 Glu allele watching TV more than 12.5 h/week (OR = 6.05; 95% CI = 1.31-27.71). Conclusion. A higher risk of obesity was found for girls carrying the 27Glu allele of the ADRB2 gene even when they spent less than 12.5 h/week watchin
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DA - Farmacia - CAFT - Artículos de revista

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