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Concurrent clarithromycin and cyclosporin A treatment
Authors: Sadaba, B. (Belén)
Lopez-de-Ocariz, A. (A.)
Azanza, J.R. (José Ramón)
Quiroga, J. (Jorge)
Cienfuegos, J.A. (Javier A.)
Keywords: Anti-Bacterial Agents/pharmacology
Immunosuppressive Agents/blood/pharmacokinetics
Issue Date: 1998
Publisher: Oxford University Press
Publisher version:
ISSN: 0305-7453
Citation: Sadaba B, Lopez de Ocariz A, Azanza JR, Quiroga J, Cienfuegos JA. Concurrent clarithromycin and cyclosporin A treatment. J Antimicrob Chemother 1998 Sep;42(3):393-395.
Although macrolides have been associated with significant pharmacokinetic interactions, clarithromycin is considered to have a low interaction capacity. In this study, six transplant recipients treated with cyclosporin A also received clarithromycin. In all patients, the dose of cyclosporin A had to be reduced by a mean of 33% per day depending on the macrolide dose. Normalization of the dosage parameters began on the fourth day after stopping clarithromycin treatment. Co-administration of cyclosporin A and clarithromycin may lead to increases in whole blood cyclosporin levels, and appropriate dose reductions should be considered.
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