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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Mazzolini, G. (Guillermo) | - |
dc.creator | Qian, C. (Cheng) | - |
dc.creator | Xie, X. (Xiaoming) | - |
dc.creator | Sun, Y. (Yonglian) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Drozdzik, M. (Marek) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.date.accessioned | 2012-04-23T07:42:51Z | - |
dc.date.available | 2012-04-23T07:42:51Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Mazzolini G, Qian C, Xie X, Sun Y, Lasarte JJ, Drozdzik M, et al. Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12. Cancer Gene Ther 1999 Nov-Dec;6(6):514-522. | es_ES |
dc.identifier.issn | 1476-5500 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21724 | - |
dc.description.abstract | Interleukin-12 (IL-12) has been shown to possess potent immunoregulatory and antitumoral effects. We have evaluated the anti-oncogenic potential and the mechanisms of the antitumoral effect of in vivo adenovirus-mediated transfer of IL-12 gene in a murine model of colon cancer. AdCMVIL-12 was constructed to permit coordinated production of p40 and p35 subunits of IL-12 gene to obtain the maximum IL-12 bioactivity. Infection of murine colon cancer CT-26 cells in vitro with AdCMVIL-12 resulted in the production of high levels of IL-12. In vivo gene therapy of colon cancer nodules by intratumoral injection of AdCMVIL-12 induced a local increase in IL-12 and interferon-gamma levels and a complete regression of the tumor in 26 of 34 (76%) mice. Tumor disappeared between days 7 and 10 after vector administration. The antitumoral effect was mediated by CD8+ T cells and was associated with the generation of cytotoxic T lymphocytes against colon cancer cells. Animals that eliminated the tumor were protected against a second administration of neoplastic cells. Treatment with AdCMVIL-12 of one tumor nodule also caused regression of established tumors at distant sites. These data demonstrate that AdCMVIL-12 is a useful therapeutic tool for established colon cancer in mice and should be considered for application in humans. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Gene therapy | es_ES |
dc.subject | Adenovirus | es_ES |
dc.subject | Interleukin-12 | es_ES |
dc.subject | Colon cancer | es_ES |
dc.subject | Animal mode | es_ES |
dc.subject | Cytotoxicity | es_ES |
dc.title | Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12 | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.nature.com/cgt/journal/v6/n6/abs/7700072a.html | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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