Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Monge, A. (Antonio) | - |
dc.creator | Alvarez, E. (E.) | - |
dc.creator | Sanmartin-Grijalba, C. (Carmen) | - |
dc.creator | Nadal, E. (Ernest) | - |
dc.creator | Ruiz, I. (I) | - |
dc.creator | Font, M. (María) | - |
dc.creator | Martinez-Irujo, J.J. (Juan José) | - |
dc.creator | Santiago, E. (Esteban) | - |
dc.creator | Prieto, I. (Inés) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.date.accessioned | 2012-04-23T07:43:16Z | - |
dc.date.available | 2012-04-23T07:43:16Z | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Monge A, Alvarez E, San Martin C, Nadal E, Ruiz I, Font M, et al. Synthesis and evaluation of new Reissert analogs as HIV-1 RT inhibitors. 2. Benzo[f]quinoline and pyridine derivatives. Drug Des Discov 1997 Apr;14(4):291-303. | es_ES |
dc.identifier.issn | 1029-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21725 | - |
dc.description.abstract | The synthesis and preliminary evaluation of new benzo[f]quinoline and pyridine derivatives, obtained by application of the Reissert method and its modifications, as HIV-1 RT inhibitors and anti-infectives are presented. The most active products against HIV-1 RT wild type are the ethyl 2-cyano-1,2-dihydrobenzo[f]quinoline-1-carboxylate 2b, propyl 2-cyano-1,2-dihydrobenzo[f]quinoline-1-carboxylate 2c, and 2-cyano-1-(2'-furoyl)-1,2-dihydrobenzo[f]quinoline 2n, which maintain their activity against the mutant type P236L, resulting inactive against the Y181C type. Using the data previously obtained by our research team for analogous series derived from quinoline as reference, the compounds which have now been obtained present an increase in the cytotoxic character attributable to the introduction of a benzene ring fused with the quinoline base nucleus, as well as a decrease of the activity as HIV-1 RT inhibitors when the quinoline benzenic ring is eliminated. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Informa Healthcare | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Anti-HIV Agents/chemical synthesis | es_ES |
dc.subject | HIV Reverse Transcriptase/antagonists & inhibitors | es_ES |
dc.subject | Pyridines/chemical synthesis | es_ES |
dc.subject | Quinolines/chemical synthesis* | es_ES |
dc.subject | Reverse Transcriptase Inhibitors/chemical synthesis | es_ES |
dc.title | Synthesis and evaluation of new Reissert analogs as HIV-1 RT inhibitors. 2. Benzo[f]quinoline and pyridine derivatives | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:eu-repo/semantics/book | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/book | es_ES |
Files in This Item:
There are no files associated with this item.
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.