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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Melero, I. (Ignacio) | - |
dc.creator | Arina, A. (Ainhoa) | - |
dc.creator | Chen, L. (Lieping) | - |
dc.date.accessioned | 2012-04-23T10:19:23Z | - |
dc.date.available | 2012-04-23T10:19:23Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Melero I, Arina A, Chen L. The many sounds of T lymphocyte silence. Immunol Res 2005;33(2):135-147. | es_ES |
dc.identifier.issn | 1559-0755 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21737 | - |
dc.description.abstract | It is not unusual for antigens and potentially responsive T cells to co-exist in the same organism while these T cells remain silent and do not mount life-threatening immune responses. A rich array of mechanisms has been proposed to explain these observations. T cell silencing is controlled in multiple levels. Initially, dendritic cells and regulatory T cells appear to play critical roles. In addition, T cell immunity is tightly regulated by a molecular network of cytokines and cell receptor interactions by the opposed surfaces of antigen-presenting cells and T cells. Recognition of a specific antigen is therefore shaped and tuned by co-stimulatory and co-inhibitory receptor-ligand pairs. At last, immunologists are beginning to exploit the rules governing these assorted sounds of T cell silence. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Humana Press | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Immunological ignorance | es_ES |
dc.subject | Tolerance | es_ES |
dc.subject | Anergy | es_ES |
dc.subject | Costimulation | es_ES |
dc.subject | T cell | es_ES |
dc.subject | Immunotherapy | es_ES |
dc.title | The many sounds of T lymphocyte silence | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.springerlink.com/content/w0245371n7232208/ | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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