Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Melero, I. (Ignacio) | - |
dc.creator | Gabari, I. (Izaskun) | - |
dc.creator | Corbi, A.L. (Angel L.) | - |
dc.creator | Relloso, M. (Miguel) | - |
dc.creator | Mazzolini, G. (Guillermo) | - |
dc.creator | Schmitz, V. (Volker) | - |
dc.creator | Rodriguez-Calvillo, M. (Mercedes) | - |
dc.creator | Tirapu, I. (Íñigo) | - |
dc.creator | Camafeita, E. (Emilio) | - |
dc.creator | Albar, J.P. (Juan P.) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.date.accessioned | 2012-04-23T13:05:07Z | - |
dc.date.available | 2012-04-23T13:05:07Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Melero I, Gabari I, Corbi AL, Relloso M, Mazzolini G, Schmitz V, et al. An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas. Cancer Res 2002 Jun 1;62(11):3167-3174. | es_ES |
dc.identifier.issn | 1538-7445 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21742 | - |
dc.description.abstract | Monoclonal antibodies (mAbs) can mediate antitumor effects by indirect mechanisms involving antiangiogenesis and up-regulation of the cellular immune response rather than by direct tumor cell destruction. From mAbs raised by immunization of rats with transformed murine endothelial cells, a mAb (EOL4G8) was selected for its ability to eradicate a fraction of established colon carcinomas that did not express the EOL4G8-recognized antigen. The antigen was found to be ICAM-2 (CD102). Antitumor effects of EOL4G8, which required a functional T-cell compartment, were abrogated by depletion of CD8(+) cells and correlated with antitumor CTL activity, whereas only a mild inhibition of angiogenesis was observed. Interestingly, we found that EOL4G8 acting on endothelial ICAM-2 markedly enhances leukotactic factor activity-1-independent adhesion of immature dendritic cells to endothelium-an effect that is at least in part mediated by DC-SIGN (CD209). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Association for Cancer Research | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Antibodies, Monoclonal/immunology | es_ES |
dc.subject | Antigens, CD/immunology | es_ES |
dc.subject | Cell Adhesion Molecules/immunology | es_ES |
dc.subject | Colonic Neoplasms/immunology | es_ES |
dc.subject | Lectins, C-Type | es_ES |
dc.title | An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://cancerres.aacrjournals.org/content/62/11/3167 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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