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dc.creatorMontserrat, L. (Lorenzo)-
dc.creatorLopez, B. (Begoña)-
dc.creatorGonzalez, A. (Arantxa)-
dc.creatorHermida, M. (Manuel)-
dc.creatorFernandez, X. (Xusto)-
dc.creatorOrtiz, M. (Martin)-
dc.creatorBarriales-Villa, R. (Roberto)-
dc.creatorCastro-Beiras, A. (Alfonso)-
dc.creatorDiez-Martinez, J. (Javier)-
dc.identifier.citationMonserrat L, Lopez B, Gonzalez A, Hermida M, Fernandez X, Ortiz M, et al. Cardiotrophin-1 plasma levels are associated with the severity of hypertrophy in hypertrophic cardiomyopathy. Eur Heart J 2011 Jan;32(2):177-183.es_ES
dc.description.abstractAbstract AIMS: Cardiotrophin-1 (CT-1) is a cytokine that induces hypertrophy in cardiomyocytes and is associated with left ventricular hypertrophy (LVH) in hypertensive patients. The objective of this study was to evaluate whether plasma CT-1 is associated with hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: The study was performed in 124 patients with HCM. All patients underwent a full clinical evaluation and an echocardiogram. Left ventricular hypertrophy was evaluated by the measurement of the maximal LV wall thickness and the Spirito's LVH score. Plasma CT-1 was measured by an enzyme-linked immunosorbent assay. Compared with controls, patients with HCM exhibited higher (P < 0.001) plasma CT-1 levels. Significant correlations were found between CT-1 and maximal LV wall thickness (r = 0.284, P = 0.001) and the Spirito's LVH score (r = 0.287, P = 0.006) in HCM patients. In addition, the levels of CT-1 were higher (P = 0.02) in patients with severe LVH (maximal LV wall thickness ≥30 mm) than in patients with mild or moderate LVH (maximal LV wall thickness <30 mm). CONCLUSIONS: These findings show that plasma CT-1 is associated with the severity of LVH in patients with HCM. Further studies are required to ascertain whether CT-1 is a diagnostic biomarker of this cardiomyopathy.es_ES
dc.publisherOxford University Presses_ES
dc.subjectHypertrophic cardiomyopathyes_ES
dc.titleCardiotrophin-1 plasma levels are associated with the severity of hypertrophy in hypertrophic cardiomyopathyes_ES

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