Full metadata record
DC Field | Value | Language |
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dc.creator | Garcia-Bolao, I. (Ignacio) | - |
dc.creator | Lopez-Salazar, M.B. (María Begoña) | - |
dc.creator | Macias, A. (Alfonso) | - |
dc.creator | Gavira, J.J. (Juan José) | - |
dc.creator | Azcarate, P.M. (Pedro María) | - |
dc.creator | Diez-Martinez, J. (Javier) | - |
dc.date.accessioned | 2012-05-02T07:49:57Z | - |
dc.date.available | 2012-05-02T07:49:57Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Garcia-Bolao I, Lopez B, Macias A, Gavira JJ, Azcarate P, Diez J. Impact of collagen type I turnover on the long-term response to cardiac resynchronization therapy. Eur Heart J 2008 Apr;29(7):898-906. | es_ES |
dc.identifier.issn | 1522-9645 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21849 | - |
dc.description.abstract | AIMS: We investigated whether collagen type I turnover influences the long-term response to cardiac resynchronization therapy (CRT). METHODS AND RESULTS: Serum carboxy-terminal propeptide of procollagen type I or PICP (a marker of collagen type I synthesis) and carboxy-terminal telopeptide of collagen type I or CITP (a marker of collagen type I degradation) were measured in heart failure patients at baseline and after 1 year of CRT. Patients were categorized as responders or non-responders if they increased the distance walked in 6 min by > or <10%, respectively. At baseline, the PICP:CITP ratio, an index of the degree of coupling between collagen type I synthesis and degradation was higher (P = 0.006) in responders than in non-responders. Whereas the PICP:CITP ratio decreased (P= 0.000) after treatment in responders, it remained unchanged in non-responders. Thus, at 1-year, the PICP:CITP ratio was similar in the two groups of patients. A direct correlation (r = 0.289, P = 0.037) was found between the baseline PICP:CITP ratio and the change in the distance walked in 6 min in all patients. Receiver operating characteristics curves showed that a cut-off value of 14.4 for the PICP:CITP ratio provided 70% specificity and 63% sensitivity for the predicting response to CRT with a relative risk of 2.07 (95% confidence interval, 0.98-4.39). CONCLUSION: Collagen type I turnover influences the long-term response to CRT. In addition, the ability of CRT to restore the balance between collagen type I synthesis and degradation is associated with a beneficial response. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Collagen | es_ES |
dc.subject | Heart failure | es_ES |
dc.subject | Resynchronization | es_ES |
dc.title | Impact of collagen type I turnover on the long-term response to cardiac resynchronization therapy | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://eurheartj.oxfordjournals.org/content/29/7/898 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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