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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

Apoptosis in hypertensive heart disease: a clinical approach
Authors: Gonzalez, A. (Arantxa)
Ravassa, S. (Susana)
Lopez, B. (Begoña)
Loperena, I. (Iñigo)
Querejeta, R. (Ramón)
Diez, J. (Javier)
Keywords: Apoptosis
Heart Failure/physiopathology
Myocytes, Cardiac
Issue Date: 2006
Publisher: Lippincott, Williams & Wilkins
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ISSN: 1531-7080
Citation: Gonzalez A, Ravassa S, Lopez B, Loperena I, Querejeta R, Diez J. Apoptosis in hypertensive heart disease: a clinical approach. Curr Opin Cardiol 2006 Jul;21(4):288-294.
PURPOSE OF REVIEW: It is widely accepted that there are two principal forms of cell death, namely, necrosis and apoptosis. According to the classical view, necrosis is the major mechanism of cardiomyocyte death in cardiac diseases. RECENT DEVELOPMENTS: In the past few years observations have been made showing that cardiomyocyte apoptosis occurs in diverse conditions including hypertensive heart disease, and that apoptosis may be a contributing cause of loss and functional abnormalities of cardiomyocytes in this condition. SUMMARY: This review will summarize recent evidence demonstrating the potential contribution of cardiomyocyte apoptosis to heart failure in hypertensive patients. In addition, some strategies aimed to detect and prevent apoptosis of cardiomyocytes will be considered.
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