Myocardial fibrosis in arterial hypertension
Keywords: 
Fibrosis
Heart failure
Hypertension
Myocardium
Remodelling
Reparation
Issue Date: 
2002
Publisher: 
Oxford University Press
ISSN: 
1554-2815
Citation: 
Gonzalez A, Lopez B, Diez J. Myocardial fibrosis in arterial hipertensión. Eur Heart J 2002;4(Supp D):D18-D22
Abstract
It is now accepted that, in addition to left ventricular hypertrophy, hypertensive heart disease is characterized by alterations in myocardial structure, leading to loss of tissue homogeneity and pathological remodelling. It is time to recognize that, in hypertensive heart disease, it is not only the quantity but also the quality of the myocardium that is responsible for adverse cardiovascular events. The data reviewed here indicate that, in patients with hypertensive heart disease, myocardial fibrosis predisposes to an enhanced risk for diastolic and/or systolic ventricular dysfunction, symptomatic heart failure, ischaemic heart disease and arrhythmias.

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