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|Association of age, inflammatory markers and subclinical atherosclerosis in subjects free from cardiovascular disease|
|Authors: ||Paramo, J.A. (José Antonio)|
Orbe, J. (Josune)
Beloqui, O. (Óscar)
Colina, I. (Inmaculada)
Benito, A. (Alberto)
Rodriguez, J.A. (José Antonio)
Diez, J. (Javier)
|Issue Date: ||2008|
|Publisher version: ||http://www.elsevier.es/en/node/2067499|
|Citation: ||Paramo JA, Orbe J, Beloqui O, Colina I, Benito A, Rodriguez JA, et al. Association of age, inflammatory markers and subclinical atherosclerosis in subjects free from cardiovascular disease. Med Clin (Barc) 2008 Sep 27;131(10):361-366.|
BACKGROUND AND OBJECTIVE: We assessed whether an independent association between inflammatory markers and age-related subclinical atherosclerosis could be found in subjects free from cardiovascular disease.
PATIENTS AND METHOD: Metabolic parameters, inflammatory and endothelial markers, such as high-sensitivity C-reactive protein, interleukin-6, fibrinogen and von Willebrand factor, as well as the carotid intima-media thickness were assessed in 890 asymptomatic subjects (mean age: 55 years; range: 20-80 years; 80% men) with cardiovascular risk factors.
RESULTS: Subjects in the upper quartile (age 61-80 years) showed a significant increase of traditional risk factors, particularly arterial pressure and glucose levels (p < 0.01) as compared with lower quartiles. We also found a significant increase in the levels on inflammatory and endothelial markers (p < 0.001) and intima-media thickness (p < 0.001) in older adults. In the multivarate analysis, after adjustment for cardiovascular risk factors, intima-media thickness was independently associated with inflammation and endothelial dysfunction in older adults (p < 0.01).
CONCLUSIONS: Besides age, systemic inflammation and vascular damage are associated with subclinical atherosclerosis in asymptomatic subjects. The age-related inflammatory profile may predispose to cardiovascular complications.
|Permanent link: ||http://hdl.handle.net/10171/21909|
|Appears in Collections:||DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista|
DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista
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