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Study of vascular risk in Navarre: objectives and design. Prevalence of metabolic syndrome and of vascular risk factors
Authors: Viñes, J.J. (José Javier)
Diez, J. (Javier)
Guembe, M.J. (María Jesús)
Gonzalez, P. (P.)
Azmequeta, C. (C)
Barba, J. (Joaquín)
Sobejano, I. (I.)
Martinez-Vila, E. (Eduardo)
Grijalba, A.M. (A. M.)
Serrano, M. (Manuel)
Moreno, C. (Cristina)
Los-Arcos, E. (E.)
Guerrero, D. (D.)
Keywords: Risk vascular factors
Sub-clinical lesions
Navarra (España)
Prevalence Metabolic Syndrome
Issue Date: 2007
Publisher: Gobierno de Navarra. Departamento de Salud
Publisher version:
ISSN: 1137-6627
Citation: Vines JJ, Diez J, Guembe MJ, Gonzalez P, Amezqueta C, Barba J, et al. Study of vascular risk in Navarre: objectives and design. Prevalence of metabolic syndrome and of vascular risk factors. An Sist Sanit Navar 2007 Jan-Apr;30(1):113-124.
BACKGROUND: To determine in a representative sample of the population the prevalence of risk factors and metabolic syndrome; their association with sub-clinical atherosclerotic lesions and their impact on cardiocerebrovascular disease 10 years after. MATERIAL AND METHODS: (Phase 1) Cross sectional survey of a random sample stratified by age and sex of the population of Navarre aged between 35 and 84. Antecedents, risk factors, physical and analytical exploration. (Phase II) Ten year follow-up cohort study, in 500 exposed to MS and 500 not exposed persons, aged between 45 and 74 years; with an 82.25% power to detect a risk ratio of 2; with analytical and image markers of sub-clinical atherosclerosis. (Phase III) Follow up of vascular events at ten years. RESULTS: The subjects recruited were 6,553; excluded or not found 871; the final sample was 5,682 (2,644 men and 3,038 women); 4,168 (73,4%) took part in the study. The prevalence of MS was 22.1% (95%CI 20.5 - 23.7) for men and 17,2% (95%CI 15.8 - 18.5) for women. The main cardiovascular RF were high compared to other geographical areas except for HDL cholesterol. The rate was 8.5% (95%CI 7.4 - 9.6) for men and 1.7% (95%CI 1.3 - 2.2) CONCLUSIONS: There are important differences in risk between sex, being worst for men. The high figures for HDL cholesterol and the low prevalence of MS might mean a lower risk of vascular events in Navarra.
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