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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

Biochemical Diagnosis of Hypertensive Myocardial Fibrosis
Authors: Diez, J. (Javier)
Laviades, C. (Concepción)
Varo, N. (Nerea)
Querejeta, R. (Ramón)
Lopez, B. (Begoña)
Keywords: Collagen
Myocardial fibrosis
Arterial hypertension
Issue Date: 2000
Publisher: Elsevier
Publisher version:
ISSN: 1579-2242
Citation: Diez J, Laviades C, Varo N, Querejeta R, Lopez B. Biochemical diagnosis of hypertensive myocardial fibrosis. Rev Esp Cardiol 2000;53(Suppl. 1):8-13.
A substantial increase in fibrillar collagen has been observed in the left cardiac ventricle of animals and humans with arterial hypertension. Hypertensive myocardial fibrosis is the result of both increased collagen types I and III due to the fact that its synthesis by fibroblasts and myofibroblasts is stimulated and its extracellular collagen degradation unchanged or decreased extracellular collagen degradation. Hemodynamic and non-hemodynamic factors may be involved in the disequilibrium between collagen synthesis and degradation that occurs in hypertension. As shown experimentally and clinically, an exaggerated rise in fibrilar collagen content promotes abnormalities of cardiac function, contributes to the decrease in coronary reserve and facilitates alterations in the electrical activity of the left ventricle. Although microscopic examination of cardiac biopsies is the most reliable method for documenting and measuring myocardial fibrosis, the development of non-invasive methods to indicate the presence of myocardial fibrosis in hypertensive patients would be useful. We have therefore applied a biochemical method based on the measurement of serum peptides derived from the tissue formation when synthesized and degradation of fibrillar collagens to monitor the turnover of these molecules in rats with spontaneous hypertension and patients with essential hypertension.
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