Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Navarro, S. (Silvia) | - |
dc.creator | Bonet, E. (Elena) | - |
dc.creator | Estelles, A. (Amparo) | - |
dc.creator | Montes, R. (Ramón) | - |
dc.creator | Hermida, J. (José) | - |
dc.creator | Martos, L. (Laura) | - |
dc.creator | España, F. (Francisco) | - |
dc.creator | Medina, P. (Pilar) | - |
dc.date.accessioned | 2012-05-09T13:04:03Z | - |
dc.date.available | 2012-05-09T13:04:03Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Navarro S, Bonet E, Estelles A, Montes R, Hermida J, Martos L, et al. The endothelial cell protein C receptor: its role in thrombosis. Thromb Res 2011 Nov;128(5):410-416. | es_ES |
dc.identifier.issn | 1879-2472 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21978 | - |
dc.description.abstract | The protein C anticoagulant pathway plays a crucial role as a regulator of the blood clotting cascade. Protein C is activated on the vascular endothelial cell membrane by the thrombin-thrombomodulin complex. The endothelial protein C receptor binds protein C and further enhances protein C activation. Once formed, activated protein C down-regulates thrombin formation by inactivating factors Va and VIIIa and exerts cytoprotective effects through endothelial protein C receptor binding. An adequate generation of activated protein C depends on the precise assembly, on the surface of the endothelial cells, of thrombin, thrombomodulin, protein C, and endothelial protein C receptor. Therefore, any change in the efficiency of this assembly may cause a reduction or increase in activated protein C generation and modulate the risk of thrombosis. This review highlights the role of the endothelial protein C receptor in disease and discusses the association of its mutations with the risk of thrombosis. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Activated protein C | es_ES |
dc.subject | Endothelial protein C receptor | es_ES |
dc.subject | Factor VII | es_ES |
dc.subject | Venous thrombosis | es_ES |
dc.subject | Myocardial infarction | es_ES |
dc.title | The endothelial cell protein C receptor: its role in thrombosis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0049384811004233 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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