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|Autoantibodies against the endothelial receptor of protein C are associated with acute myocardial infarction in young women|
|Authors: ||Montes, R. (Ramón)|
Hurtado, V. (Verónica)
Alonso, A. (Andrés)
Foco, L. (L.)
Zonzin, P. (P.)
Mannucci, P.M. (P.M.)
Hermida, J. (José)
|Issue Date: ||2005|
|Publisher version: ||http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2005.01297.x/abstract|
|Citation: ||Montes R, Hurtado V, Alonso A, Foco L, Zonzin P, Mannucci PM, et al. Autoantibodies against the endothelial receptor of protein C are associated with acute myocardial infarction in young women. J Thromb Haemost 2005 Jul;3(7):1454-1458.|
BACKGROUND: Acute myocardial infarction (AMI) is rare among young women. The search for unknown risk factors is warranted. Endothelial protein C receptor (EPCR) is largely present at the endothelial surface of large arteries. No studies about association of anti-EPCR autoantibodies (anti-EPCR) with AMI are available.
METHODS: Plasma IgA, IgM and IgG anti-EPCR levels were measured by enzyme-linked immunosorbent assay in 165 women younger than 45 years who survived a first AMI and 165 healthy women, matched by age and geographical origin.
RESULTS: Using the 90th percentile of IgA anti-EPCR in the control group, IgA anti-EPCR were independently associated with AMI after adjustment for cardiovascular risk factors (OR 5.1; 95% CI 1.7-15.6; P = 0.004). The risk apparently conferred by IgA anti-EPCR increased dose-dependently (P for trend =0.0002). IgM anti-EPCR were less consistently associated with AMI: a significant increase in the risk was found when women above the 90th percentile were compared with those in the lowest quartile (OR 3.6; 95% CI 1.2-11.5; P = 0.03). IgG anti-EPCR were similar in patients and controls. A total of 145 patients underwent coronary arteriography. IgA or IgM anti-EPCR were not different among patients with different degrees of atherosclerotic lesion (anova, P = 0.77 and 0.24, respectively).
CONCLUSIONS: High levels of IgA and, to a lesser extent, IgM anti-EPCR, are associated with AMI in young women.
|Permanent link: ||http://hdl.handle.net/10171/21991|
|Appears in Collections:||DA - CIMA - Cardiovasculares - Trombosis y Hemostasia - Artículos de Revista|
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