Beneficial aspects of vascular apoptosis in hypertensive heart disease
Keywords: 
Hypertensive heart disease
Vascular apoptosis
Issue Date: 
2000
Publisher: 
Krause and Pachernegg
ISSN: 
1680-9386
Citation: 
Diez J, Fortuno MA, Gonzalez A, Ravassa S, Zalba G. Beneficial aspects of vascular apoptosis in hypertensive heart disease. J Clin Basic Cardiol 2000;3(1):61-62.
Abstract
Arterial hypertension may be viewed as a generalized vascular disorder, with an imbalance between proliferation and apoptosis of vascular smooth muscle cells. As a consequence exaggerated accumulation of these cells may result leading to an encroachment of the tunica media into the lumen. This geometric abnormality of the vessel wall may play a critical role in the long-term maintenance of elevated blood pressure and development of hypertensive endorgan damage. In this short paper, we summarize data on alterations in the growth and death of vascular smooth muscle cells in the small coronary arteries in hypertension.

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