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|Prevalence of left ventricular diastolic dysfunction in European populations based on cross-validated diagnostic thresholds|
|Authors: ||Kloch-Badelek, M. (Malgorzata)|
Kuznetsova, T. (Tatiana)
Sakiewicz, W. (Wojciech)
Tikhonoff, V. (Valerie)
Ryabikov, A. (Andrew)
Gonzalez, A. (Arantxa)
Lopez, B. (Begoña)
Thijs, L. (Lutgarde)
Jin, Y. (Yu)
Malyutina, S. (Sofía)
Stolarz-Skrzypek, K. (Katarzyna)
Casiglia, E. (Edoardo)
Diez, J. (Javier)
Narkiewicz, K. (Krzysztof)
Kawecka-Jaszcz, K. (Kalina)
Staessen, J.A. (Jan A.)
|Keywords: ||Ventricular Dysfunction, Left/etiology|
|Issue Date: ||2012|
|Publisher: ||BioMed Central|
|Publisher version: ||http://www.cardiovascularultrasound.com/content/10/1/10/abstract|
|Citation: ||Kloch-Badelek M, Kuznetsova T, Sakiewicz W, Tikhonoff V, Ryabikov A, Gonzalez A, et al. Prevalence of left ventricular diastolic dysfunction in European populations based on cross-validated diagnostic thresholds. Cardiovasc Ultrasound 2012 Mar 19;10(1):10.|
BACKGROUND: Different diagnostic criteria limit comparisons between populations in the prevalence of diastolic left ventricular (LV) dysfunction. We aimed to compare across populations age-specific echocardiographic criteria for diastolic LV dysfunction as well as their correlates and prevalence.
METHODS: We measured the E and A peaks of transmitral blood flow by pulsed wave Doppler and the e' and a' peaks of mitral annular velocities by tissue Doppler imaging (TDI) in 2 cohorts randomly recruited in Belgium (n = 782; 51.4% women; mean age, 51.1 years) and in Italy, Poland and Russia (n = 476; 55.7%; 44.5 years).
RESULTS: In stepwise regression, the multivariable-adjusted correlates of the transmitral and TDI diastolic indexes were similar in the 2 cohorts and included sex, age, body mass index, blood pressure and heart rate. Similarly, cut-off limits for the E/A ratio (2.5th percentile) and E/e' ratio (97.5th percentile) in 338 and 185 reference subjects free from cardiovascular risk factors respectively selected from both cohorts were consistent within 0.02 and 0.26 units (median across 5 age groups). The rounded 2.5th percentile of the E/A ratio decreased by ~0.10 per age decade in these apparently healthy subjects. The reference subsample provided age-specific cut-off limits for normal E/A and E/e' ratios. In the 2 cohorts combined, diastolic dysfunction groups 1 (impaired relaxation), 2 (possible elevated LV filling pressure) and 3 (elevated E/e' and abnormally low E/A) encompassed 114 (9.1%), 135 (10.7%), and 40 (3.2%) subjects, respectively.
CONCLUSIONS: The age-specific criteria for diastolic LV dysfunction were highly consistent across the study populations with an age-standardized prevalence of 22.4% vs. 25.1%.
|Permanent link: ||http://hdl.handle.net/10171/22024|
|Appears in Collections:||DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista|
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