Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Montes, R. (Ramón) | - |
dc.creator | Declerck, P.J. (Paul J.) | - |
dc.creator | Calvo-González, A. (Alfonso) | - |
dc.creator | Montes, M. (Marta) | - |
dc.creator | Hermida, J. (José) | - |
dc.creator | Muñoz, M.C. (María Carmen) | - |
dc.creator | Rocha, E. (Eduardo) | - |
dc.date.accessioned | 2012-05-18T17:20:00Z | - |
dc.date.available | 2012-05-18T17:20:00Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Montes R, Declerck PJ, Calvo A, Montes M, Hermida J, Munoz MC, et al. Prevention of renal fibrin deposition in endotoxin-induced DIC through inhibition of PAI-1. Thromb Haemost 2000 Jul;84(1):65-70. | es_ES |
dc.identifier.issn | 0340-6245 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22121 | - |
dc.description.abstract | Plasminogen activator inhibitor-1 (PAI-1) increases in endotoxemia thus possibly cooperating in altering the hemostatic balance in a prothrombotic direction. The effect of the inhibition of PAI-1 with the monoclonal antibody MA-33B8 was studied systemically and in kidneys in a lapine model of endotoxin-induced disseminated intravascular coagulation (DIC). The increase in plasmatic PAI activity in the control group (n = 9) was inhibited in the MA-33B8 treated rabbits (n = 5). Control rabbits showed renal fibrin deposits, whereas only one of the MA-33B8 rabbits did so. These results were confirmed immunohistochemically in kidneys as PAI-1 immunostaining was seen inside the glomeruli and larger vessels in the control group, whereas MA-33B8 rabbits showed a remarkable decrease, demonstrating that MA-33B8 successfully inhibited PAI-1 in the kidneys as well. Therefore evidence for the important role of PAI-1 in fibrin generation in endotoxin-induced DIC is presented, suggesting that strategies aiming at its reduction can be useful in this pathology. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Schattauer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | PAI-1 | es_ES |
dc.subject | Sepsis | es_ES |
dc.subject | Endotoxemia | es_ES |
dc.subject | Monoclonal antibodies | es_ES |
dc.subject | Kidney | es_ES |
dc.title | Prevention of renal fibrin deposition in endotoxin-induced DIC through inhibition of PAI-1 | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://bit.ly/LenEy0 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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