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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Trombosis y hemostasia > DA - CIMA - Cardiovasculares - Trombosis y Hemostasia - Artículos de Revista >

Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death
Authors: Hurtado, V. (Verónica)
Montes, R. (Ramón)
Gris, J.C. (Jean-Christophe)
Bertolaccini, M.L. (María L.)
Alonso, A. (Alvaro)
Martinez-Gonzalez, M.A. (Miguel Ángel)
Khamashta, M.A. (Munther A.)
Fukudome, K. (Kenji)
Lane, D.A. (David A.)
Hermida, J. (José)
Keywords: Antiphospholipid syndrome/immunology
Fetal death/immunology
Pregnancy complications/immunology
Issue Date: 2004
Publisher: American Society of Hematology
Publisher version:
ISSN: 1528-0020
Citation: Hurtado V, Montes R, Gris JC, Bertolaccini ML, Alonso A, Martinez-Gonzalez MA, et al. Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death. Blood 2004 Sep 1;104(5):1369-1374.
The antiphospholipid syndrome (APS) is associated with thrombosis and fetal death but the pathologic mechanisms are poorly understood. Since endothelial protein C receptor (EPCR) plays a role in the anticoagulant system and in placental development, we hypothesized that anti-EPCR autoantibodies may be involved in clinical manifestations of APS and in fetal loss. The levels of immunoglobulin M (IgM) and IgG anti-EPCR autoantibodies were analyzed by enzyme-linked immunosorbent assay (ELISA) in 43 patients with APS and 43 controls. Anti-EPCR levels were higher in APS patients than in controls. Interestingly, one of the IgM anti-EPCR autoantibodies inhibited the generation of activated protein C on endothelium. Since markedly high anti-EPCR levels were found in women with fetal death, 87 patients with a first episode of unexplained fetal death were subsequently analyzed and their anti-EPCR levels were compared with 87 matched controls. We found that anti-EPCR autoantibodies constitute an independent risk factor for a first fetal death episode: the adjusted odds ratios (ORs) for anti-EPCR autoantibodies above the 95th percentile were 23.0 (95% confidence interval [CI], 2.0-266.3) for IgM and 6.8 (95% CI, 1.2-38.4) for IgG. Anti-EPCR autoantibodies can be detected in APS patients and are independent risk factors for fetal death.
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Appears in Collections:DA - Medicina - MPSP -Artículos de revista
DA - CIMA - Cardiovasculares - Trombosis y Hemostasia - Artículos de Revista

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