Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Hurtado, V. (Verónica) | - |
dc.creator | Montes, R. (Ramón) | - |
dc.creator | Gris, J.C. (Jean-Christophe) | - |
dc.creator | Bertolaccini, M.L. (María L.) | - |
dc.creator | Alonso, A. (Alvaro) | - |
dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.creator | Khamashta, M.A. (Munther A.) | - |
dc.creator | Fukudome, K. (Kenji) | - |
dc.creator | Lane, D.A. (David A.) | - |
dc.creator | Hermida, J. (José) | - |
dc.date.accessioned | 2012-05-28T15:58:37Z | - |
dc.date.available | 2012-05-28T15:58:37Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Hurtado V, Montes R, Gris JC, Bertolaccini ML, Alonso A, Martinez-Gonzalez MA, et al. Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death. Blood 2004 Sep 1;104(5):1369-1374. | es_ES |
dc.identifier.issn | 1528-0020 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22273 | - |
dc.description.abstract | The antiphospholipid syndrome (APS) is associated with thrombosis and fetal death but the pathologic mechanisms are poorly understood. Since endothelial protein C receptor (EPCR) plays a role in the anticoagulant system and in placental development, we hypothesized that anti-EPCR autoantibodies may be involved in clinical manifestations of APS and in fetal loss. The levels of immunoglobulin M (IgM) and IgG anti-EPCR autoantibodies were analyzed by enzyme-linked immunosorbent assay (ELISA) in 43 patients with APS and 43 controls. Anti-EPCR levels were higher in APS patients than in controls. Interestingly, one of the IgM anti-EPCR autoantibodies inhibited the generation of activated protein C on endothelium. Since markedly high anti-EPCR levels were found in women with fetal death, 87 patients with a first episode of unexplained fetal death were subsequently analyzed and their anti-EPCR levels were compared with 87 matched controls. We found that anti-EPCR autoantibodies constitute an independent risk factor for a first fetal death episode: the adjusted odds ratios (ORs) for anti-EPCR autoantibodies above the 95th percentile were 23.0 (95% confidence interval [CI], 2.0-266.3) for IgM and 6.8 (95% CI, 1.2-38.4) for IgG. Anti-EPCR autoantibodies can be detected in APS patients and are independent risk factors for fetal death. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society of Hematology | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Antiphospholipid syndrome/immunology | es_ES |
dc.subject | Autoantibodies/blood | es_ES |
dc.subject | Endothelins/immunology | es_ES |
dc.subject | Fetal death/immunology | es_ES |
dc.subject | Pregnancy complications/immunology | es_ES |
dc.title | Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://bloodjournal.hematologylibrary.org/content/104/5/1369 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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