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Edad del donante y su influencia en la supervivencia del injerto
Other Titles: Influence of donor age on graft survival
Authors: Barba, J.F. (Javier Fermín)
Tolosa-Eizaguirre, E. (Egoitz)
Rincon-Mayans, A. (Anibal)
Rosell, D. (David)
Robles, J.E. (José Enrique)
Zudaire, J.J. (Juan Javier)
Berian-Polo, J.M. (José María)
Pascual-Piedrola, J.I. (Juan Ignacio)
Keywords: Graft survival
Donor age
Renal transplant
Issue Date: 2010
Publisher: Elsevier España
Publisher version:
ISSN: 0210-4806
Citation: Barba Abad J, Tolosa Eizaguirre E, Rincon Mayans A, Rosell Costa D, Robles Garcia JE, Zudaire Bergera J, et al. Edad del donante y su influencia en la supervivencia del injerto. Actas Urol Esp 2010 Sep;34(8):719-725
INTRODUCTION: In 2007 in Spain 43% of donors were older than 60 years. This produces a worse graft quality and probably a worse survival. OBJECTIVE: Our objective is to analyze the influence of donor age on graft survival. MATERIAL AND METHODS: We analyze retrospectively 216 renal consecutive transplants realized between 2000 and 2008. A univaried and multivaried study (Cox regression) was performed and Kaplan-Meyer test with log rank for graft survival. RESULTS: Follow-up mean of 40 months (+/-33,4 SD). The univaried analysis of graft survival showed that donor age had a significative influence on graft survival. (OR=1,03; 95% CI 1,01-1,05) (p: 0,009). Studying the relation between donor and recipient age we find an inverse correlation (Pearson's Correlation: 0,55. p<0,0001), but there are significative differences after the adjustment for recipient age. (OR: 1,02; 95% CI 1,01-1,04) (p: 0,04). Optimal cut-point value determined by the ROC analysis was 60 years. The graft survival of donors over 60 years is 79% (95% CI; 74-84%) and 71% (95% CI; 65-77%) at 3 and 5 years in contrast with 94% (95% CI; 94-96%) and 90% (95% CI; 88-92 in donors under 60. (p: 0,002). The multivaried study of the influential factors on graft survival reveals that donor age dichotomized in older or younger than 60, the presence of a surgical immediate reintervention and a delayed graft function were independent influence factors. CONCLUSIONS: Donor age over 60 years has a negative and independent prognostic influence on graft survival.
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