D'Avola D, Herrero JI. Prophylaxis and treatment of hepatitis B infection in the setting of liver transplantation. Rev Esp Enferm Dig 2011 Mar;103(3):142-149.
Without any treatment, the prognosis of hepatitis B in liver
transplant recipients is very poor. So, antiviral prophylaxis is very
important in patients with hepatitis B who undergo liver transplantation.
Before liver transplantation, a suppression of viral
replication has to be achieved by nucleos(t)ide analogs. Drugs used
in the prophylaxis of post-transplant hepatitis B include immunoglobulin
against HBV and nucleos(t)ide analogs. Prophylaxis
against graft infection must be based on the individual risk of recurrence.
When prophylactic measures have failed and graft infection
has occurred, treatment of recurrent hepatitis B may be
based on the resistance profile of the virus and previous antiviral
exposure. Finally, lamivudine seems to be very effective in the
prevention of de novo hepatitis B in patients transplanted with a
graft from an anti-HBc positive donor.