Prophylaxis and treatment of hepatitis B infection in the setting of liver transplantation
Other Titles: 
Profilaxis y tratamiento de la infección por hepatitis B en el contexto de trasplante de hígado.
Keywords: 
Liver transplantation
Prophylaxis
Hepatitis B
Issue Date: 
2011
Publisher: 
The Spanish Society of Digestive Pathology
ISSN: 
1130-0108
Citation: 
D'Avola D, Herrero JI. Prophylaxis and treatment of hepatitis B infection in the setting of liver transplantation. Rev Esp Enferm Dig 2011 Mar;103(3):142-149.
Abstract
Without any treatment, the prognosis of hepatitis B in liver transplant recipients is very poor. So, antiviral prophylaxis is very important in patients with hepatitis B who undergo liver transplantation. Before liver transplantation, a suppression of viral replication has to be achieved by nucleos(t)ide analogs. Drugs used in the prophylaxis of post-transplant hepatitis B include immunoglobulin against HBV and nucleos(t)ide analogs. Prophylaxis against graft infection must be based on the individual risk of recurrence. When prophylactic measures have failed and graft infection has occurred, treatment of recurrent hepatitis B may be based on the resistance profile of the virus and previous antiviral exposure. Finally, lamivudine seems to be very effective in the prevention of de novo hepatitis B in patients transplanted with a graft from an anti-HBc positive donor.

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