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|Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass|
|Authors: ||Catalan, V. (Victoria)|
Gomez-Ambrosi, J. (Javier)
Rodriguez, A. (Amaia)
Ramirez, B. (Beatriz)
Rotellar, F. (Fernando)
Valenti, V. (Víctor)
Silva, C. (Camilo)
Gil, M.J. (María José)
Salvador, J. (Javier)
Frühbeck, G. (Gema)
|Keywords: ||Diabetes mellitus, type 2/complications/metabolism/surgery|
|Issue Date: ||2011|
|Publisher: ||Endocrine Society|
|Publisher version: ||http://jcem.endojournals.org/content/96/1/200.full.pdf+html|
|Citation: ||Catalan V, Gomez-Ambrosi J, Rodriguez A, Ramirez B, Rotellar F, Valenti V, et al. Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass. J Clin Endocrinol Metab 2011 Jan;96(1):200-209.|
Context: Plasma YKL-40 is elevated in patients with type 2 diabetes. The potential role of visceral
adipose tissue (VAT) as a significant source of YKL-40 is unknown.
Objective: In the study circulating and expression levels of YKL-40 were examined in VAT analyzing
the contribution of adipocytes and stromovascular fraction cells (SVFCs).Wealso explored YKL-40’s
implication in insulin resistance and inflammation and the effect of weight loss on plasma YKL-40
PatientsandMethods: Samples obtained from 53 subjects were used in the study.Geneandprotein
expression levels of YKL-40 were analyzed in VAT as well as in both adipocytes and SVFCs. In
addition, circulating YKL-40 concentrations were measured before and after weight loss achieved
either by Roux-en-Y gastric bypass (n 26) or after a conventional dietetic program (n 20).
Results: Circulating concentrations and VAT expression of YKL-40 were increased in obese patients
with type 2 diabetes (P 0.01) as well as associated with variables of insulin resistance and inflammation.
No differences in YKL-40 expression levels between adipocytes and SVFCs were detected.
Monocyte chemoattractant protein-1 and homeostasis model assessment emerged (P
0.01) as independent factors predicting circulating YKL-40. Elevated levels of YKL-40 in obese
patients decreased after weight loss following a conventional hypocaloric diet (P 0.05) but not
via a surgery-induced negative energy balance mediated by the Roux-en-Y gastric bypass.
Conclusions: The association of increased YKL-40 mRNA and protein levels in VAT with its circulating
concentrations indicates an important contribution of VAT in YKL-40 regulation. Furthermore,
our data suggest a relevant role of glucose metabolism and inflammation on YKL-40
|Permanent link: ||http://hdl.handle.net/10171/22483|
|Appears in Collections:||DA - Medicina - Endocrinología - Artículos de revista|
DA - Medicina - Cirugía General - Artículos de revista
DA - CUN - Bioquímica clínica - Artículos de revista
DA - CIFA - Laboratorio de investigación metabólica - Artículos de Revista
DA - CUN - Endocrinología y Nutrición - Artículos de revista
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