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dc.creatorCatalan, V. (Victoria)-
dc.creatorGomez-Ambrosi, J. (Javier)-
dc.creatorRodriguez, A. (Amaia)-
dc.creatorRamirez, B. (Beatriz)-
dc.creatorRotellar, F. (Fernando)-
dc.creatorValenti, V. (Victor)-
dc.creatorSilva, C. (Camilo)-
dc.creatorGil, M.J. (María José)-
dc.creatorSalvador, J. (Javier)-
dc.creatorFrühbeck, G. (Gema)-
dc.date.accessioned2012-06-05T18:17:15Z-
dc.date.available2012-06-05T18:17:15Z-
dc.date.issued2011-
dc.identifier.citationCatalan V, Gomez-Ambrosi J, Rodriguez A, Ramirez B, Rotellar F, Valenti V, et al. Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass. J Clin Endocrinol Metab 2011 Jan;96(1):200-209.es_ES
dc.identifier.issn0021-972X-
dc.identifier.urihttp://hdl.handle.net/10171/22483-
dc.description.abstractContext: Plasma YKL-40 is elevated in patients with type 2 diabetes. The potential role of visceral adipose tissue (VAT) as a significant source of YKL-40 is unknown. Objective: In the study circulating and expression levels of YKL-40 were examined in VAT analyzing the contribution of adipocytes and stromovascular fraction cells (SVFCs).Wealso explored YKL-40’s implication in insulin resistance and inflammation and the effect of weight loss on plasma YKL-40 concentrations. PatientsandMethods: Samples obtained from 53 subjects were used in the study.Geneandprotein expression levels of YKL-40 were analyzed in VAT as well as in both adipocytes and SVFCs. In addition, circulating YKL-40 concentrations were measured before and after weight loss achieved either by Roux-en-Y gastric bypass (n 26) or after a conventional dietetic program (n 20). Results: Circulating concentrations and VAT expression of YKL-40 were increased in obese patients with type 2 diabetes (P 0.01) as well as associated with variables of insulin resistance and inflammation. No differences in YKL-40 expression levels between adipocytes and SVFCs were detected. Monocyte chemoattractant protein-1 and homeostasis model assessment emerged (P 0.01) as independent factors predicting circulating YKL-40. Elevated levels of YKL-40 in obese patients decreased after weight loss following a conventional hypocaloric diet (P 0.05) but not via a surgery-induced negative energy balance mediated by the Roux-en-Y gastric bypass. Conclusions: The association of increased YKL-40 mRNA and protein levels in VAT with its circulating concentrations indicates an important contribution of VAT in YKL-40 regulation. Furthermore, our data suggest a relevant role of glucose metabolism and inflammation on YKL-40 regulation.es_ES
dc.language.isoenges_ES
dc.publisherEndocrine Societyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectDiabetes mellitus, type 2/complications/metabolism/surgeryes_ES
dc.subjectGlycoproteins/metabolismes_ES
dc.subjectGastric bypasses_ES
dc.titleIncreased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypasses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://jcem.endojournals.org/content/96/1/200.full.pdf+htmles_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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