Full metadata record
DC Field | Value | Language |
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dc.creator | Catalan, V. (Victoria) | - |
dc.creator | Gomez-Ambrosi, J. (Javier) | - |
dc.creator | Rodriguez, A. (Amaia) | - |
dc.creator | Ramirez, B. (Beatriz) | - |
dc.creator | Rotellar, F. (Fernando) | - |
dc.creator | Valenti, V. (Víctor) | - |
dc.creator | Silva, C. (Camilo) | - |
dc.creator | Gil, M.J. (María José) | - |
dc.creator | Salvador, J. (Javier) | - |
dc.creator | Frühbeck, G. (Gema) | - |
dc.date.accessioned | 2012-06-05T18:17:15Z | - |
dc.date.available | 2012-06-05T18:17:15Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Catalan V, Gomez-Ambrosi J, Rodriguez A, Ramirez B, Rotellar F, Valenti V, et al. Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass. J Clin Endocrinol Metab 2011 Jan;96(1):200-209. | es_ES |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://hdl.handle.net/10171/22483 | - |
dc.description.abstract | Context: Plasma YKL-40 is elevated in patients with type 2 diabetes. The potential role of visceral adipose tissue (VAT) as a significant source of YKL-40 is unknown. Objective: In the study circulating and expression levels of YKL-40 were examined in VAT analyzing the contribution of adipocytes and stromovascular fraction cells (SVFCs).Wealso explored YKL-40’s implication in insulin resistance and inflammation and the effect of weight loss on plasma YKL-40 concentrations. PatientsandMethods: Samples obtained from 53 subjects were used in the study.Geneandprotein expression levels of YKL-40 were analyzed in VAT as well as in both adipocytes and SVFCs. In addition, circulating YKL-40 concentrations were measured before and after weight loss achieved either by Roux-en-Y gastric bypass (n 26) or after a conventional dietetic program (n 20). Results: Circulating concentrations and VAT expression of YKL-40 were increased in obese patients with type 2 diabetes (P 0.01) as well as associated with variables of insulin resistance and inflammation. No differences in YKL-40 expression levels between adipocytes and SVFCs were detected. Monocyte chemoattractant protein-1 and homeostasis model assessment emerged (P 0.01) as independent factors predicting circulating YKL-40. Elevated levels of YKL-40 in obese patients decreased after weight loss following a conventional hypocaloric diet (P 0.05) but not via a surgery-induced negative energy balance mediated by the Roux-en-Y gastric bypass. Conclusions: The association of increased YKL-40 mRNA and protein levels in VAT with its circulating concentrations indicates an important contribution of VAT in YKL-40 regulation. Furthermore, our data suggest a relevant role of glucose metabolism and inflammation on YKL-40 regulation. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Endocrine Society | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Diabetes mellitus, type 2/complications/metabolism/surgery | es_ES |
dc.subject | Glycoproteins/metabolism | es_ES |
dc.subject | Gastric bypass | es_ES |
dc.title | Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://jcem.endojournals.org/content/96/1/200.full.pdf+html | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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